Naonori Ohno1, Hideki Murai1, Yukihisa Suzuki1, Motohiro Kiyosawa2, Aya M Tokumaru3, Kenji Ishii4, Kyoko Ohno-Matsui5. 1. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. 2. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Kiyosawa Eye Clinic, Tokyo, Japan. 3. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. 4. Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. 5. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Abstract
PURPOSE: To evaluate alteration of the optic radiation (OR) in patients with retinitis pigmentosa (RP) using fractional anisotropy (FA) measured by diffusion tensor MRI. METHODS: We performed MRI and evaluated alteration of the ORs in 17 patients with RP and 27 healthy controls. Regions of interest were placed over the bilateral anterior and posterior areas of the ORs, and we measured the FA value of each region. Visual field (VF) tests were examined in all subjects, and we corrected the residual VF area according to the projection area to the striate cortex. Differences between the FA values of patients and healthy controls were tested. We performed regression analyses between the sum of the corrected VF areas and FA values in the anterior or posterior contralateral ORs in patients with RP. Moreover, we performed regression analyses between the average of FA values of ORs and the average of both eyes of visual acuity in patients with RP. RESULTS: FA values of the bilateral anterior and posterior ORs were lower in patients with RP (anterior right, p=0.012; posterior right, p=0.0004; anterior left, p=0.0008; and posterior left, p=0.0004) compared with those of healthy controls. In patients with RP, significant correlations were observed between average FA values of anterior ORs and average visual acuity (correlation coefficient (r)=-0.54; p=0.025). CONCLUSIONS: In patients with RP, alterations may occur not only in the retina but also in the brain. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
PURPOSE: To evaluate alteration of the optic radiation (OR) in patients with retinitis pigmentosa (RP) using fractional anisotropy (FA) measured by diffusion tensor MRI. METHODS: We performed MRI and evaluated alteration of the ORs in 17 patients with RP and 27 healthy controls. Regions of interest were placed over the bilateral anterior and posterior areas of the ORs, and we measured the FA value of each region. Visual field (VF) tests were examined in all subjects, and we corrected the residual VF area according to the projection area to the striate cortex. Differences between the FA values of patients and healthy controls were tested. We performed regression analyses between the sum of the corrected VF areas and FA values in the anterior or posterior contralateral ORs in patients with RP. Moreover, we performed regression analyses between the average of FA values of ORs and the average of both eyes of visual acuity in patients with RP. RESULTS: FA values of the bilateral anterior and posterior ORs were lower in patients with RP (anterior right, p=0.012; posterior right, p=0.0004; anterior left, p=0.0008; and posterior left, p=0.0004) compared with those of healthy controls. In patients with RP, significant correlations were observed between average FA values of anterior ORs and average visual acuity (correlation coefficient (r)=-0.54; p=0.025). CONCLUSIONS: In patients with RP, alterations may occur not only in the retina but also in the brain. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Jan Lestak; Jiri Chod; Jozef Rosina; Karel Hana Journal: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Date: 2022-06-14 Impact factor: 1.648
Authors: Konstantin N Loganovsky; Donatella Marazziti; Pavlo A Fedirko; Kostiantyn V Kuts; Katerina Y Antypchuk; Iryna V Perchuk; Tetyana F Babenko; Tetyana K Loganovska; Olena O Kolosynska; George Y Kreinis; Marina V Gresko; Sergii V Masiuk; Federico Mucci; Leonid L Zdorenko; Alessandra Della Vecchia; Natalia A Zdanevich; Natalia A Garkava; Raisa Y Dorichevska; Zlata L Vasilenko; Victor I Kravchenko; Nataliya V Drosdova Journal: Life (Basel) Date: 2020-04-16