Literature DB >> 25636653

Enoyl-coenzyme A hydratase in cancer.

Jun Zhang1, M M Ibrahim1, Mingzhong Sun2, Jianwu Tang3.   

Abstract

Enoyl-CoA hydratase (Ech) catalyzes the second step in the physiologically important beta-oxidation pathway of fatty acid metabolism. The enzyme was reported to be associated with the progression, metastasis and drug resistance of cancers. It might function as a tumor promoter or a tumor suppressor for certain cancers depending on the particular type or stage of tumor cells/tissues. In this review, Ech's association with malignant tumors as well as its potential mechanisms is discussed and summarized. The enzyme might be useful in the diagnosis, treatment and prognosis determination of certain tumors.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Beta-oxidation; Cancer; Enoyl-CoA hydratase (Ech); Fatty acid degradation

Mesh：

Substances：

Year:  2015        PMID： 25636653     DOI： 10.1016/j.cca.2015.01.020

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


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