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Literature DB >> 25635221

Emerging therapy for adrenocortical carcinoma.

Abstract

Adrenocortical carcinoma (ACC) is a very rare and aggressive tumor with dismal outcomes. Best current treatments include complete surgical resection for localized resectable disease and systemic therapy with mitotane alone or in combination for advanced ACC. Advances in molecular genetic profiling of ACC have created multiple new targets for potential treatment options in ACC. This article reviews the current treatment options available for ACC and discusses the potential new targets identified through molecular profiling.

Entities: CellLine Chemical Disease Gene Species

Keywords: adrenocortical carcinoma; genomics; molecular profiling; systemic treatment

Year: 2014 PMID： 25635221 PMCID： PMC4307842 DOI： 10.2217/ije.14.13

Source DB: PubMed Journal: Int J Endocr Oncol ISSN： 2045-0869

92 in total

Review 1. Transcriptome analysis of adrenocortical cancers: from molecular classification to the identification of new treatments.

Authors: Bruno Ragazzon; Guillaume Assié; Jérôme Bertherat
Journal: Endocr Relat Cancer Date: 2011-02-23 Impact factor: 5.678

2. Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial.

Authors: Alfredo Berruti; Massimo Terzolo; Paola Sperone; Anna Pia; Silvia Della Casa; David J Gross; Carlo Carnaghi; Paolo Casali; Francesco Porpiglia; Franco Mantero; Giuseppe Reimondo; Alberto Angeli; Luigi Dogliotti
Journal: Endocr Relat Cancer Date: 2005-09 Impact factor: 5.678

3. Antiestrogens upregulate estrogen receptor beta expression and inhibit adrenocortical H295R cell proliferation.

Authors: D Montanaro; M Maggiolini; A G Recchia; R Sirianni; S Aquila; L Barzon; F Fallo; S Andò; V Pezzi
Journal: J Mol Endocrinol Date: 2005-10 Impact factor: 5.098

4. SF-1 overexpression in childhood adrenocortical tumours.

Authors: Mara A D Pianovski; Luciane R Cavalli; Bonald C Figueiredo; Savana C L Santos; Mabrouka Doghman; Raul C Ribeiro; Antonio G Oliveira; Edson Michalkiewicz; Giovanna A Rodrigues; Gerard Zambetti; Bassem R Haddad; Enzo Lalli
Journal: Eur J Cancer Date: 2006-03-29 Impact factor: 9.162

5. Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells.

Authors: Lidia Cerquetti; Camilla Sampaoli; Donatella Amendola; Barbara Bucci; Laura Masuelli; Rodolfo Marchese; Silvia Misiti; Agostino De Venanzi; Maurizio Poggi; Vincenzo Toscano; Antonio Stigliano
Journal: Exp Cell Res Date: 2011-03-03 Impact factor: 3.905

6. Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.

Authors: Gwenaelle Abiven; Joel Coste; Lionel Groussin; Philippe Anract; Frédérique Tissier; Paul Legmann; Bertrand Dousset; Xavier Bertagna; Jérôme Bertherat
Journal: J Clin Endocrinol Metab Date: 2006-05-02 Impact factor: 5.958

7. Phase I clinical trial of lenalidomide in combination with temsirolimus in patients with advanced cancer.

Authors: Prasanth Ganesan; Sarina Piha-Paul; Aung Naing; Gerald Falchook; Jennifer Wheler; Filip Janku; Ralph Zinner; Shell Laday; Merrill Kies; Apostolia M Tsimberidou
Journal: Invest New Drugs Date: 2013-08-28 Impact factor: 3.850

8. Sustained remission with the kinase inhibitor sorafenib in stage IV metastatic adrenocortical carcinoma.

Authors: Charles Butler; William M Butler; Ali A Rizvi
Journal: Endocr Pract Date: 2010 May-Jun Impact factor: 3.443

9. Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.

Authors: J P Luton; S Cerdas; L Billaud; G Thomas; B Guilhaume; X Bertagna; M H Laudat; A Louvel; Y Chapuis; P Blondeau
Journal: N Engl J Med Date: 1990-04-26 Impact factor: 91.245

10. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.

Authors: Arash Hossein-nezhad; Avrum Spira; Michael F Holick
Journal: PLoS One Date: 2013-03-20 Impact factor: 3.240

7 in total

Emerging therapy for adrenocortical carcinoma.

Review 1. Transcriptome analysis of adrenocortical cancers: from molecular classification to the identification of new treatments.

2. Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial.

3. Antiestrogens upregulate estrogen receptor beta expression and inhibit adrenocortical H295R cell proliferation.

4. SF-1 overexpression in childhood adrenocortical tumours.

5. Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells.

6. Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.

7. Phase I clinical trial of lenalidomide in combination with temsirolimus in patients with advanced cancer.

8. Sustained remission with the kinase inhibitor sorafenib in stage IV metastatic adrenocortical carcinoma.

9. Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.

10. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.

1. Does Lymphadenectomy Improve Survival in Patients with Adrenocortical Carcinoma? A Population-Based Study.

2. Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma.

3. Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms.

4. Adrenocortical carcinoma: modern management and evolving treatment strategies.

5. Adrenocortical carcinoma with inferior vena cava, left renal vein and right atrium tumor thrombus extension.

Review 6. Successful treatment of metastatic adrenocortical carcinoma in the spine: A case report and literature review.

7. Identification of a chromatin regulator signature and potential prognostic ability for adrenocortical carcinoma.