Literature DB >> 2563508

Predisposing locus for Alzheimer's disease on chromosome 21.

A M Goate1, A R Haynes, M J Owen, M Farrall, L A James, L Y Lai, M J Mullan, P Roques, M N Rossor, R Williamson.   

Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

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Year:  1989        PMID： 2563508     DOI： 10.1016/s0140-6736(89)91725-x

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  40 in total

1.  Alzheimer disease: the new agenda.

Authors:  J Hardy; M C Chartier-Harlin; M Mullan
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

2.  Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.

Authors: 
Journal:  BMJ       Date:  1991-02-09

3.  The genetics of Alzheimer disease--a teasing problem.

Authors:  J L Haines
Journal:  Am J Hum Genet       Date:  1991-06       Impact factor: 11.025

4.  Segregation analysis reveals evidence of a major gene for Alzheimer disease.

Authors:  L A Farrer; R H Myers; L Connor; L A Cupples; J H Growdon
Journal:  Am J Hum Genet       Date:  1991-06       Impact factor: 11.025

5.  Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

Authors:  M A Pericak-Vance; J L Bebout; P C Gaskell; L H Yamaoka; W Y Hung; M J Alberts; A P Walker; R J Bartlett; C A Haynes; K A Welsh
Journal:  Am J Hum Genet       Date:  1991-06       Impact factor: 11.025

6.  A contiguous Not I restriction map of band q22.3 of human chromosome 21.

Authors:  D Wang; H Fang; C R Cantor; C L Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

7.  Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

Authors:  R E Tanzi; G Vaula; D M Romano; M Mortilla; T L Huang; R G Tupler; W Wasco; B T Hyman; J L Haines; B J Jenkins
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

8.  Gene mutations in inherited amyloidopathies of the nervous system.

Authors:  R E Tanzi
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

9.  Distribution of interspersed repeats (Alu and Kpn) on NotI restriction fragments of human chromosome 21.

Authors:  J Sainz; L Pevny; Y Wu; C R Cantor; C L Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-01       Impact factor: 11.205

Review 10.  Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.

Authors:  H Potter
Journal:  Am J Hum Genet       Date:  1991-06       Impact factor: 11.025
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