Literature DB >> 25634616

PI3Kβ inhibition: all that glitters is not gold.

Mauro Torti1.   

Abstract

In this issue of Blood, Laurent et al demonstrate that phosphatidylinositol 3-kinase β (PI3Kβ) activity is essential for thrombus stability at a high shear rate, highlighting a potential risk of embolization upon PI3Kβ inhibition.

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Year:  2015        PMID： 25634616     DOI： 10.1182/blood-2014-12-612564

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  4 in total

1.  Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases.

Authors:  Ahmed F Abdel-Magid
Journal:  ACS Med Chem Lett       Date:  2017-07-06       Impact factor: 4.345

Review 2.  Phosphoinositide 3-Kinases as Potential Targets for Thrombosis Prevention.

Authors:  Natasha M Setiabakti; Pia Larsson; Justin R Hamilton
Journal:  Int J Mol Sci       Date:  2022-04-27       Impact factor: 6.208

3.  In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Authors:  Tom N Durrant; James L Hutchinson; Kate J Heesom; Karen E Anderson; Len R Stephens; Phillip T Hawkins; Aaron J Marshall; Samantha F Moore; Ingeborg Hers
Journal:  Blood Adv       Date:  2017-06-13

Review 4.  PI3K inhibitors in thrombosis and cardiovascular disease.

Authors:  Tom N Durrant; Ingeborg Hers
Journal:  Clin Transl Med       Date:  2020-01-31
  4 in total

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