Literature DB >> 25634485

A DN-mda5 transgenic zebrafish model demonstrates that Mda5 plays an important role in snakehead rhabdovirus resistance.

K A Gabor1, J R Charette2, M J Pietraszewski2, D J Wingfield2, J S Shim2, P J Millard1, C H Kim3.   

Abstract

Melanoma Differentiation-Associated protein 5 (MDA5) is a member of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family, which is a cytosolic pattern recognition receptor that detects viral nucleic acids. Here we show an Mda5-dependent response to rhabdovirus infection in vivo using a dominant-negative mda5 transgenic zebrafish. Dominant-negative mda5 zebrafish embryos displayed an impaired antiviral immune response compared to wild-type counterparts that can be rescued by recombinant full-length Mda5. To our knowledge, we have generated the first dominant-negative mda5 transgenic zebrafish and demonstrated a critical role for Mda5 in the antiviral response to rhabdovirus.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antiviral; Danio rerio; Mda5; Rhabdovirus; Type I IFN; Zebrafish

Mesh：

Substances：

Year:  2015        PMID： 25634485      PMCID： PMC4442029          DOI： 10.1016/j.dci.2015.01.006

Source DB:  PubMed          Journal:  Dev Comp Immunol        ISSN： 0145-305X            Impact factor:   3.636


  60 in total

1.  Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition.

Authors:  Alys Peisley; Cecilie Lin; Bin Wu; McGhee Orme-Johnson; Mengyuan Liu; Thomas Walz; Sun Hur
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-12       Impact factor: 11.205

2.  Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.

Authors:  Eva Kowalinski; Thomas Lunardi; Andrew A McCarthy; Jade Louber; Joanna Brunel; Boyan Grigorov; Denis Gerlier; Stephen Cusack
Journal:  Cell       Date:  2011-10-14       Impact factor: 41.582

3.  Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.

Authors:  Xiaojun Li; Cheng Lu; Mikaela Stewart; Hengyu Xu; Roland K Strong; Tatyana Igumenova; Pingwei Li
Journal:  Arch Biochem Biophys       Date:  2009-06-14       Impact factor: 4.013

4.  Heritable gene targeting in zebrafish using customized TALENs.

Authors:  Peng Huang; An Xiao; Mingguo Zhou; Zuoyan Zhu; Shuo Lin; Bo Zhang
Journal:  Nat Biotechnol       Date:  2011-08-05       Impact factor: 54.908

5.  Pathogen recognition receptors in channel catfish: II. Identification, phylogeny and expression of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs).

Authors:  K V Rajendran; Jiaren Zhang; Shikai Liu; Eric Peatman; Huseyin Kucuktas; Xiuli Wang; Hong Liu; Theresa Wood; Jeffery Terhune; Zhanjiang Liu
Journal:  Dev Comp Immunol       Date:  2012-02-28       Impact factor: 3.636

Review 6.  Immune signaling by RIG-I-like receptors.

Authors:  Yueh-Ming Loo; Michael Gale
Journal:  Immunity       Date:  2011-05-27       Impact factor: 31.745

7.  Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss).

Authors:  Mingxian Chang; Bertrand Collet; Pin Nie; Katherine Lester; Scott Campbell; Christopher J Secombes; Jun Zou
Journal:  J Virol       Date:  2011-06-15       Impact factor: 5.103

8.  Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.

Authors:  Alina Baum; Ravi Sachidanandam; Adolfo García-Sastre
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-30       Impact factor: 11.205

9.  Structural insights into RNA recognition by RIG-I.

Authors:  Dahai Luo; Steve C Ding; Adriana Vela; Andrew Kohlway; Brett D Lindenbach; Anna Marie Pyle
Journal:  Cell       Date:  2011-10-14       Impact factor: 41.582

Review 10.  Host-pathogen interactions made transparent with the zebrafish model.

Authors:  Annemarie H Meijer; Herman P Spaink
Journal:  Curr Drug Targets       Date:  2011-06       Impact factor: 3.465
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  4 in total

Review 1.  Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives.

Authors:  Shan Nan Chen; Peng Fei Zou; Pin Nie
Journal:  Immunology       Date:  2017-02-28       Impact factor: 7.397

Review 2.  Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways.

Authors:  Yajuan Li; Yuelong Li; Xiaocong Cao; Xiangyu Jin; Tengchuan Jin
Journal:  Cell Mol Immunol       Date:  2016-10-10       Impact factor: 11.530

Review 3.  Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review.

Authors:  Jassy Mary S Lazarte; Kim D Thompson; Tae Sung Jung
Journal:  Front Immunol       Date:  2019-04-26       Impact factor: 7.561

Review 4.  Cytosolic Sensors for Pathogenic Viral and Bacterial Nucleic Acids in Fish.

Authors:  Miriam Mojzesz; Krzysztof Rakus; Magdalena Chadzinska; Kentaro Nakagami; Gouranga Biswas; Masahiro Sakai; Jun-Ichi Hikima
Journal:  Int J Mol Sci       Date:  2020-10-02       Impact factor: 5.923
  4 in total

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