Literature DB >> 25634383

Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities.

Christiane Reitz1.   

Abstract

Alzheimer's disease (AD), the most common form of dementia in western societies, is a pathologically and clinically heterogeneous disease with a strong genetic component. The recent advances in high-throughput genome technologies allowing for the rapid analysis of millions of polymorphisms in thousands of subjects has significantly advanced our understanding of the genomic underpinnings of AD susceptibility. During the last 5 years, genome-wide association and whole-exome- and whole-genome sequencing studies have mapped more than 20 disease-associated loci, providing insights into the molecular pathways involved in AD pathogenesis and hinting at potential novel therapeutic targets. This review article summarizes the challenges and opportunities of when using genomic information for the diagnosis and prognosis of AD.

Entities:  

Keywords:  Alzheimer’s disease; diagnosis; genomics; prognosis; therapy

Mesh：

Substances：

Year:  2015        PMID： 25634383      PMCID： PMC4677675          DOI： 10.1586/14737159.2015.1002469

Source DB:  PubMed          Journal:  Expert Rev Mol Diagn        ISSN： 1473-7159            Impact factor:   5.225


  117 in total

1.  Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.

Authors:  Michael Ewers; Zhenyu Zhong; Katharina Bürger; Anders Wallin; Kaj Blennow; Stefan J Teipel; Yong Shen; Harald Hampel
Journal:  Brain       Date:  2008-03-11       Impact factor: 13.501

2.  Personal genomes: The case of the missing heritability.

Authors:  Brendan Maher
Journal:  Nature       Date:  2008-11-06       Impact factor: 49.962

3.  Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.

Authors:  Kim A Celone; Vince D Calhoun; Bradford C Dickerson; Alireza Atri; Elizabeth F Chua; Saul L Miller; Kristina DePeau; Doreen M Rentz; Dennis J Selkoe; Deborah Blacker; Marilyn S Albert; Reisa A Sperling
Journal:  J Neurosci       Date:  2006-10-04       Impact factor: 6.167

Review 4.  Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments.

Authors:  Eric M Reiman; Jessica B S Langbaum; Adam S Fleisher; Richard J Caselli; Kewei Chen; Napatkamon Ayutyanont; Yakeel T Quiroz; Kenneth S Kosik; Francisco Lopera; Pierre N Tariot
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

5.  Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy.

Authors:  A M Remes; S Finnilä; H Mononen; H Tuominen; R Takalo; R Herva; K Majamaa
Journal:  Neurology       Date:  2004-07-27       Impact factor: 9.910

6.  Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease.

Authors:  T Gomez-Isla; H L West; G W Rebeck; S D Harr; J H Growdon; J J Locascio; T T Perls; L A Lipsitz; B T Hyman
Journal:  Ann Neurol       Date:  1996-01       Impact factor: 10.422

7.  A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment.

Authors:  M C Tierney; J P Szalai; W G Snow; R H Fisher; T Tsuda; H Chi; D R McLachlan; P H St George-Hyslop
Journal:  Neurology       Date:  1996-01       Impact factor: 9.910

Review 8.  Complement receptor 1 (CR1) and Alzheimer's disease.

Authors:  Helen Crehan; Patrick Holton; Selina Wray; Jennifer Pocock; Rita Guerreiro; John Hardy
Journal:  Immunobiology       Date:  2011-07-23       Impact factor: 3.144

9.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330

10.  Missense variant in TREML2 protects against Alzheimer's disease.

Authors:  Bruno A Benitez; Sheng Chih Jin; Rita Guerreiro; Rob Graham; Jenny Lord; Denise Harold; Rebecca Sims; Jean-Charles Lambert; J Raphael Gibbs; Jose Bras; Celeste Sassi; Oscar Harari; Sarah Bertelsen; Michelle K Lupton; John Powell; Celine Bellenguez; Kristelle Brown; Christopher Medway; Patrick C G Haddick; Marcel P van der Brug; Tushar Bhangale; Ward Ortmann; Tim Behrens; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg; Jonathan L Haines; Jim Turton; Anne Braae; Imelda Barber; Anne M Fagan; David M Holtzman; John C Morris; Julie Williams; John S K Kauwe; Philippe Amouyel; Kevin Morgan; Andy Singleton; John Hardy; Alison M Goate; Carlos Cruchaga
Journal:  Neurobiol Aging       Date:  2013-12-21       Impact factor: 4.673
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  12 in total

1.  Dementia: What pharmacists need to know.

Authors:  Silvia Duong; Tejal Patel; Feng Chang
Journal:  Can Pharm J (Ott)       Date:  2017-02-07

2.  Multi-omics Evidence for Inheritance of Energy Pathways in Red Blood Cells.

Authors:  Erin M M Weisenhorn; Thomas J van T Erve; Nicholas M Riley; John R Hess; Thomas J Raife; Joshua J Coon
Journal:  Mol Cell Proteomics       Date:  2016-10-24       Impact factor: 5.911

3.  Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression.

Authors:  Michelle Go; Jinghong Kou; Jeong-Eun Lim; Junling Yang; Ken-Ichiro Fukuchi
Journal:  Biochem Biophys Res Commun       Date:  2016-09-15       Impact factor: 3.575

4.  Specific Signatures of Serum miRNAs as Potential Biomarkers to Discriminate Clinically Similar Neurodegenerative and Vascular-Related Diseases.

Authors:  Cristina Barbagallo; Giovanni Mostile; Gloriangela Baglieri; Flavia Giunta; Antonina Luca; Loredana Raciti; Mario Zappia; Michele Purrello; Marco Ragusa; Alessandra Nicoletti
Journal:  Cell Mol Neurobiol       Date:  2019-11-06       Impact factor: 5.046

Review 5.  Contributive Role of Hyperglycemia and Hypoglycemia Towards the Development of Alzheimer's Disease.

Authors:  Riya Chakrabarty; Sumaira Yousuf; Mahendra P Singh
Journal:  Mol Neurobiol       Date:  2022-05-03       Impact factor: 5.590

6.  Establishment and Analysis of a Combined Diagnostic Model of Alzheimer's Disease With Random Forest and Artificial Neural Network.

Authors:  Dazhong Sun; Haojun Peng; Zhibing Wu
Journal:  Front Aging Neurosci       Date:  2022-06-30       Impact factor: 5.702

7.  MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1.

Authors:  Jie Qu; Xiaowei Xiong; Gulibaha Hujie; Jun Ren; Lihui Yan; Liqun Ma
Journal:  Cell Cycle       Date:  2021-09-29       Impact factor: 5.173

8.  Integrated identification of key genes and pathways in Alzheimer's disease via comprehensive bioinformatical analyses.

Authors:  Tingting Yan; Feng Ding; Yan Zhao
Journal:  Hereditas       Date:  2019-07-16       Impact factor: 3.271

Review 9.  Precision Medicine for Alzheimer's Disease Prevention.

Authors:  Cara L Berkowitz; Lisa Mosconi; Olivia Scheyer; Aneela Rahman; Hollie Hristov; Richard S Isaacson
Journal:  Healthcare (Basel)       Date:  2018-07-13

10.  Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates.

Authors:  D M Vargas; M A De Bastiani; E R Zimmer; F Klamt
Journal:  Alzheimers Res Ther       Date:  2018-06-23       Impact factor: 6.982
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