| Literature DB >> 25634263 |
Abstract
DQAsomes (dequalinium-based liposome-like vesicles) are the prototype for all mitochondria-targeted vesicular pharmaceutical nanocarrier systems. First described in 1998, they have been successfully explored for the delivery of DNA and low-molecular weight molecules to mitochondria within living mammalian cells. Potential areas of application involve mitochondrial gene therapy, antioxidant therapy as well as apoptosis-based anticancer chemotherapy. Here, detailed protocols for the preparation, characterization, and application of DQAsomes are given.Entities:
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Year: 2015 PMID： 25634263 DOI： 10.1007/978-1-4939-2288-8_1
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745