| Literature DB >> 25633778 |
Kazuyuki Sato1, Hirotaka Sakai, Masayuki Kato, Yuji Nishio, Yuka Tsuruoka, Yu Uemura, Satoshi Yokoi, Tasuku Saito, Manabu Matsunawa, Yoshinori Suzuki, Yasushi Isobe, Yasuyuki Inoue, Masatomo Takahashi, Ikuo Miura.
Abstract
We describe herein the case of a 64-year-old man with a diagnosis of plasma cell myeloma (PCM). A chromosome analysis based on G-banding and spectral karyotyping revealed the following complex karyotype: 46,XY,del(3)(p?), t(4;15)(q31;q24),t(9;14;11)(p13;q32;q13),add(15)(q24),add(18)(q21). Fluorescence in situ hybridization (FISH) detected one signal each for the immunoglobulin heavy chain (IGH) and cyclin D1 (CCND1) genes, and three fusion signals of IGH and CCND1. FISH analysis of metaphase spreads revealed fusion signals on the derivative chromosomes 9, 11, and 14. Immunohistochemical analysis identified abnormal expression of CCND1 and PAX5. PAX5-positive PCM is rare because the down-regulation of PAX5 is essential for the terminal differentiation of B cells into plasma cells. To the best of our knowledge, this is the first reported case of a novel complex variant translocation of t(11;14)(q13;q32) and t(9;14)(p13;q32).Entities:
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Year: 2015 PMID： 25633778 DOI： 10.1007/s12185-015-1749-5
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490