Literature DB >> 2563251

The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.

N K Spurr1, A C Gough, K Stevenson, C R Wolf.   

Abstract

The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.

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Year:  1989        PMID： 2563251     DOI： 10.1007/BF00293896

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  25 in total

1.  Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

Authors:  P H Beaune; D R Umbenhauer; R W Bork; R S Lloyd; F P Guengerich
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

2.  The P450 gene superfamily: recommended nomenclature.

Authors:  D W Nebert; M Adesnik; M J Coon; R W Estabrook; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson; B Kemper; W Levin
Journal:  DNA       Date:  1987-02

Review 3.  P450 genes: structure, evolution, and regulation.

Authors:  D W Nebert; F J Gonzalez
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

4.  "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1984-02       Impact factor: 3.365

5.  Rapid transfer of DNA from agarose gels to nylon membranes.

Authors:  K C Reed; D A Mann
Journal:  Nucleic Acids Res       Date:  1985-10-25       Impact factor: 16.971

6.  Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.

Authors:  F J Gonzalez; B J Schmid; M Umeno; O W Mcbride; J P Hardwick; U A Meyer; H V Gelboin; J R Idle
Journal:  DNA       Date:  1988-03

7.  Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family.

Authors:  F J Gonzalez; D W Nebert; J P Hardwick; C B Kasper
Journal:  J Biol Chem       Date:  1985-06-25       Impact factor: 5.157

8.  Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

Authors:  F J Gonzalez; F Vilbois; J P Hardwick; O W McBride; D W Nebert; H V Gelboin; U A Meyer
Journal:  Genomics       Date:  1988-02       Impact factor: 5.736

9.  A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing.

Authors:  J S Miles; N K Spurr; A C Gough; T Jowett; A W McLaren; J D Brook; C R Wolf
Journal:  Nucleic Acids Res       Date:  1988-07-11       Impact factor: 16.971

10.  Immunoglobulin heavy chain genes in humans are located on chromosome.

Authors:  M J Hobart; T H Rabbitts; P N Goodfellow; E Solomon; S Chambers; N Spurr; S Povey
Journal:  Ann Hum Genet       Date:  1981-10       Impact factor: 1.670
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  3 in total

Review 1.  Pharmacogenomics of CYP3A: considerations for HIV treatment.

Authors:  Sukhwinder S Lakhman; Qing Ma; Gene D Morse
Journal:  Pharmacogenomics       Date:  2009-08       Impact factor: 2.533

2.  Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

Authors:  J S Miles; W Bickmore; J D Brook; A W McLaren; R Meehan; C R Wolf
Journal:  Nucleic Acids Res       Date:  1989-04-25       Impact factor: 16.971

3.  Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.

Authors:  Andrew G McArthur; Tove Hegelund; Rachel L Cox; John J Stegeman; Mette Liljenberg; Urban Olsson; Per Sundberg; Malin C Celander
Journal:  J Mol Evol       Date:  2003-08       Impact factor: 2.395
  3 in total

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