Literature DB >> 25632306

The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol.

Wan-Ru Lee1, Tomonori Ishikawa2, Michihisa Umetani1.   

Abstract

Oxysterols are metabolites of cholesterol that are produced in liver and other peripheral tissues as a means to eliminate cholesterol to bile acid. Recent studies have revealed that the most abundant circulating oxysterol 27-hydroxycholesterol (27HC) is the first identified endogenous selective estrogen receptor modulator. 27HC levels correlate well with that of cholesterol, and also rise progressively with age. 27HC affects estrogen receptor function by the antagonism of estrogen action and also by the direct modulation of the receptor function, and similar to estrogen/estrogen receptors, 27HC has many actions in various tissues. This review article introduces the recent progress in the understanding of the role of 27HC in breast cancer and cardiovascular dysfunction.

Entities:  

Keywords:  27-hydroxycholesterol; CYP27A1; CYP7B1; SERM; atherosclerosis; breast cancer; cholesterol metabolite; estrogen receptor; oxysterol

Year:  2014        PMID： 25632306      PMCID： PMC4306277          DOI： 10.2217/clp.14.53

Source DB:  PubMed          Journal:  Clin Lipidol        ISSN： 1758-4302


  73 in total

1.  Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.

Authors:  Hirdesh Uppal; Simrat P S Saini; Antonio Moschetta; Ying Mu; Jie Zhou; Haibiao Gong; Yonggong Zhai; Songrong Ren; George K Michalopoulos; David J Mangelsdorf; Wen Xie
Journal:  Hepatology       Date:  2007-02       Impact factor: 17.425

2.  The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.

Authors:  Michihisa Umetani; Pritam Ghosh; Tomonori Ishikawa; Junko Umetani; Mohamed Ahmed; Chieko Mineo; Philip W Shaul
Journal:  Cell Metab       Date:  2014-06-19       Impact factor: 27.287

3.  Disruption of the oxysterol 7alpha-hydroxylase gene in mice.

Authors:  J Li-Hawkins; E G Lund; S D Turley; D W Russell
Journal:  J Biol Chem       Date:  2000-06-02       Impact factor: 5.157

4.  In vivo and in vitro regulation of sterol 27-hydroxylase in the liver during the acute phase response. potential role of hepatocyte nuclear factor-1.

Authors:  R A Memon; A H Moser; J K Shigenaga; C Grunfeld; K R Feingold
Journal:  J Biol Chem       Date:  2001-06-13       Impact factor: 5.157

5.  Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis.

Authors:  Joanne M Upston; Xianwa Niu; Andrew J Brown; Ryuichi Mashima; Hongjie Wang; Revathy Senthilmohan; Anthony J Kettle; Roger T Dean; Roland Stocker
Journal:  Am J Pathol       Date:  2002-02       Impact factor: 4.307

6.  27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

Authors:  Erik R Nelson; Suzanne E Wardell; Jeff S Jasper; Sunghee Park; Sunil Suchindran; Matthew K Howe; Nicole J Carver; Ruchita V Pillai; Patrick M Sullivan; Varun Sondhi; Michihisa Umetani; Joseph Geradts; Donald P McDonnell
Journal:  Science       Date:  2013-11-29       Impact factor: 47.728

7.  A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians.

Authors:  J Jakobsson; H Karypidis; J-E Johansson; H-K Roh; A Rane; L Ekström
Journal:  Pharmacogenomics J       Date:  2004       Impact factor: 3.550

8.  CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5.

Authors:  Cyril Goizet; Amir Boukhris; Alexandra Durr; Christian Beetz; Jeremy Truchetto; Christelle Tesson; Maria Tsaousidou; Sylvie Forlani; Lucie Guyant-Maréchal; Bertrand Fontaine; João Guimarães; Bertrand Isidor; Olivier Chazouillères; Dominique Wendum; Djamel Grid; Françoise Chevy; Patrick F Chinnery; Paula Coutinho; Jean-Philippe Azulay; Imed Feki; Fanny Mochel; Claude Wolf; Chokri Mhiri; Andrew Crosby; Alexis Brice; Giovanni Stevanin
Journal:  Brain       Date:  2009-05-12       Impact factor: 13.501

9.  Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.

Authors:  Li-Ping Sun; Joachim Seemann; Joseph L Goldstein; Michael S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-11       Impact factor: 11.205

10.  Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.

Authors:  I Björkhem; O Andersson; U Diczfalusy; B Sevastik; R J Xiu; C Duan; E Lund
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205
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  12 in total

1.  Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.

Authors:  Olga V Fedorova; Valentina I Zernetkina; Victoria Y Shilova; Yulia N Grigorova; Ondrej Juhasz; Wen Wei; Courtney A Marshall; Edward G Lakatta; Alexei Y Bagrov
Journal:  Circ Cardiovasc Genet       Date:  2015-09-15

Review 2.  27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator.

Authors:  Sisi He; Erik R Nelson
Journal:  Maturitas       Date:  2017-07-31       Impact factor: 4.342

3.  Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer.

Authors:  Nan Ge; Xiu-Mei Chu; Yun-Peng Xuan; Dun-Qiang Ren; Yongjie Wang; Kai Ma; Hui-Jiang Gao; Wen-Jie Jiao
Journal:  Oncol Lett       Date:  2017-10-10       Impact factor: 2.967

4.  Circulating lipids, mammographic density, and risk of breast cancer in the Nurses' Health Study and Nurses' Health Study II.

Authors:  Sarah A Lucht; A Heather Eliassen; Kimberly A Bertrand; Thomas P Ahern; Signe Borgquist; Bernard Rosner; Susan E Hankinson; Rulla M Tamimi
Journal:  Cancer Causes Control       Date:  2019-07-01       Impact factor: 2.506

5.  The 14-3-3η/GSK-3β/β-catenin complex regulates EndMT induced by 27-hydroxycholesterol in HUVECs and promotes the migration of breast cancer cells.

Authors:  Jing Zhen; Kailin Jiao; Keke Yang; Maoxuan Wu; Qian Zhou; Bingmo Yang; Wei Xiao; Chunyan Hu; Ming Zhou; Zhong Li
Journal:  Cell Biol Toxicol       Date:  2020-11-01       Impact factor: 6.691

Review 6.  Hormonal and Genetic Regulatory Events in Breast Cancer and Its Therapeutics: Importance of the Steroidogenic Acute Regulatory Protein.

Authors:  Pulak R Manna; Ahsen U Ahmed; Deborah Molehin; Madhusudhanan Narasimhan; Kevin Pruitt; P Hemachandra Reddy
Journal:  Biomedicines       Date:  2022-06-03

7.  PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead.

Authors:  Khaldoun S Abdelwahed; Abu Bakar Siddique; Mohammed H Qusa; Judy Ann King; Soumaya Souid; Zakaria Y Abd Elmageed; Khalid A El Sayed
Journal:  ACS Pharmacol Transl Sci       Date:  2021-10-05

Review 8.  Re-adopting classical nuclear receptors by cholesterol metabolites.

Authors:  Michihisa Umetani
Journal:  J Steroid Biochem Mol Biol       Date:  2015-11-10       Impact factor: 4.292

9.  Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.

Authors:  Quanri Liu; Yu An; Huanling Yu; Yanhui Lu; Lingli Feng; Chao Wang; Rong Xiao
Journal:  Lipids Health Dis       Date:  2016-10-10       Impact factor: 3.876

Review 10.  Our evolving understanding of how 27-hydroxycholesterol influences cancer.

Authors:  Liqian Ma; Wonhwa Cho; Erik R Nelson
Journal:  Biochem Pharmacol       Date:  2021-05-24       Impact factor: 5.858
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