AIM: To investigate the impact of enteral nutrition (EN) on the body composition and metabolism in patients with Crohn's disease (CD). METHODS: Sixty-one patients diagnosed with CD were enrolled in this study. They were given only EN (enteral nutritional suspension, TPF, non-elemental diet) support for 4 wk, without any treatment with corticosteroids, immunosuppressive drugs, infliximab or by surgical operation. Body composition statistics such as weight, body mass index, skeletal muscle mass (SMM), fat mass, protein mass and inflammation indexes such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and CD activity index (CDAI) were recorded before and after EN support. RESULTS: The 61 patients were divided into three groups according to CDAI before and after EN support: A (active phase into remission via EN, n=21), B (remained in active phase before and after EN, n=19) and C (in remission before and after EN, n=21). Patients in group A had a significant increase in SMM (22.11±4.77 kg vs 23.23±4.49 kg, P=0.044), protein mass (8.01±1.57 kg vs 8.44±1.45 kg, P=0.019) and decrease in resting energy expenditure (REE) per kilogram (27.42±5.01 kcal/kg per day vs 22.62±5.45 kcal/kg per day, P<0.05). There was no significant difference between predicted and measured REE in active CD patients according to the Harris-Benedict equation. There was no linear correlation between the measured REE and CRP, ESR or CDAI in active CD patients. CONCLUSION: EN could decrease the hypermetabolism in active CD patients by reducing the inflammatory response.
AIM: To investigate the impact of enteral nutrition (EN) on the body composition and metabolism in patients with Crohn's disease (CD). METHODS: Sixty-one patients diagnosed with CD were enrolled in this study. They were given only EN (enteral nutritional suspension, TPF, non-elemental diet) support for 4 wk, without any treatment with corticosteroids, immunosuppressive drugs, infliximab or by surgical operation. Body composition statistics such as weight, body mass index, skeletal muscle mass (SMM), fat mass, protein mass and inflammation indexes such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and CD activity index (CDAI) were recorded before and after EN support. RESULTS: The 61 patients were divided into three groups according to CDAI before and after EN support: A (active phase into remission via EN, n=21), B (remained in active phase before and after EN, n=19) and C (in remission before and after EN, n=21). Patients in group A had a significant increase in SMM (22.11±4.77 kg vs 23.23±4.49 kg, P=0.044), protein mass (8.01±1.57 kg vs 8.44±1.45 kg, P=0.019) and decrease in resting energy expenditure (REE) per kilogram (27.42±5.01 kcal/kg per day vs 22.62±5.45 kcal/kg per day, P<0.05). There was no significant difference between predicted and measured REE in active CDpatients according to the Harris-Benedict equation. There was no linear correlation between the measured REE and CRP, ESR or CDAI in active CDpatients. CONCLUSION: EN could decrease the hypermetabolism in active CDpatients by reducing the inflammatory response.
Entities:
Keywords:
Body composition; Crohn’s disease; Enteral nutrition; Metabolism
Authors: S Takagi; K Utsunomiya; S Kuriyama; H Yokoyama; S Takahashi; M Iwabuchi; H Takahashi; S Takahashi; Y Kinouchi; N Hiwatashi; Y Funayama; I Sasaki; I Tsuji; T Shimosegawa Journal: Aliment Pharmacol Ther Date: 2006-11-01 Impact factor: 8.171
Authors: V Varille; J P Cézard; P de Lagausie; M Bellaiche; P Tounian; M Besnard; C Faure; Y Aigrain; J P Girardet; J Navarro Journal: J Pediatr Gastroenterol Nutr Date: 1996-07 Impact factor: 2.839
Authors: A Diamanti; M S Basso; M Gambarara; B Papadatou; F Bracci; C Noto; M Castro Journal: Int J Colorectal Dis Date: 2008-09-17 Impact factor: 2.571
Authors: Amy Hsu; Stanley Heshka; Isaac Janumala; Mi-Yeon Song; Mary Horlick; Norman Krasnow; Dympna Gallagher Journal: Am J Clin Nutr Date: 2003-06 Impact factor: 7.045