Jian-Bing Wang1, Sanford M Dawsey2, Jin-Hu Fan3, Neal D Freedman2, Ze-Zhong Tang4, Ti Ding4, Nan Hu5, Le-Min Wang5, Chao-Yu Wang5, Hua Su5, You-Lin Qiao6, Alisa M Goldstein5, Philip R Taylor5, Christian C Abnet7. 1. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 20850 MD, USA; Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China; Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, 310058 Hangzhou, China. 2. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 20850 MD, USA. 3. Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China. 4. Shanxi Cancer Hospital, 030013 Taiyuan, China. 5. Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 20850 MD, USA. 6. Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China. Electronic address: qiaoy@cicams.ac.cn. 7. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 20850 MD, USA. Electronic address: abnetc@mail.nih.gov.
Abstract
BACKGROUND: Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC). METHODS: We evaluated the association between 12 single nucleotide polymorphisms (SNPs) in four genes related to vitamin D levels and ESCC risk using data from a genome-wide association study. Participants were recruited from the Shanxi Upper Gastrointestinal Cancer Genetics Project and the Linxian Nutrition Intervention Trials, and included 1942 ESCC cases and 2111 controls. We used logistic models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the SNP associations, after controlling for age and gender. RESULTS: None of the 12 evaluated SNPs in the four vitamin D-related genes were significantly associated with risk of ESCC. The strongest associations were for rs3794060 (P=0.07) and rs12800438 (P=0.08) in the DHCR7/NADSYN1 gene. No association between vitamin D-related SNPs and risk of ESCC was observed in a genotype score analysis that included all 12 SNPs. ORs for quartiles 2, 3 and 4 of the genotype scores were 0.83 (95% CI: 0.68, 1.01), 1.02 (0.85, 1.21), and 1.08 (0.89, 1.30), respectively, with no evidence for a significant monotonic trend (P=0.120). CONCLUSIONS: Our results suggested that common genetic variants related to vitamin D levels are not associated with risk of ESCC in this Chinese population. Published by Elsevier Ltd.
BACKGROUND: Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC). METHODS: We evaluated the association between 12 single nucleotide polymorphisms (SNPs) in four genes related to vitamin D levels and ESCC risk using data from a genome-wide association study. Participants were recruited from the Shanxi Upper Gastrointestinal Cancer Genetics Project and the Linxian Nutrition Intervention Trials, and included 1942 ESCC cases and 2111 controls. We used logistic models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the SNP associations, after controlling for age and gender. RESULTS: None of the 12 evaluated SNPs in the four vitamin D-related genes were significantly associated with risk of ESCC. The strongest associations were for rs3794060 (P=0.07) and rs12800438 (P=0.08) in the DHCR7/NADSYN1 gene. No association between vitamin D-related SNPs and risk of ESCC was observed in a genotype score analysis that included all 12 SNPs. ORs for quartiles 2, 3 and 4 of the genotype scores were 0.83 (95% CI: 0.68, 1.01), 1.02 (0.85, 1.21), and 1.08 (0.89, 1.30), respectively, with no evidence for a significant monotonic trend (P=0.120). CONCLUSIONS: Our results suggested that common genetic variants related to vitamin D levels are not associated with risk of ESCC in this Chinese population. Published by Elsevier Ltd.
Entities:
Keywords:
China; Esophageal squamous cell carcinoma; Genetic variants; Vitamin D
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