Literature DB >> 25631169

Altered neurochemical coupling in the occipital cortex in migraine with visual aura.

Holly Bridge1, Charlotte J Stagg2, Jamie Near3, Chi-ieong Lau4, Aimee Zisner5, M Zameel Cader6.   

Abstract

BACKGROUND: Visual aura is present in about one-third of migraine patients and triggering by bright or flickering lights is frequently reported.
METHOD: Using migraine with visual aura patients, we investigated the neurochemical profile of the visual cortex using magnetic resonance spectroscopy. Specifically, glutamate/creatine and GABA/creatine ratios were quantified in the occipital cortex of female migraine patients.
RESULTS: GABA levels in the occipital cortex of migraine patients were lower than that of controls. Glutamate levels in migraine patients, but not controls, correlated with the blood-oxygenation-level-dependent (BOLD) signal in the primary visual cortex during visual stimulation.
CONCLUSION: Migraine with visual aura appears to disrupt the excitation-inhibition coupling in the occipital cortex. © International Headache Society 2015.

Entities:  

Keywords:  GABA; Migraine; glutamate; magnetic resonance spectroscopy; visual cortex

Mesh:

Substances:

Year:  2015        PMID: 25631169     DOI: 10.1177/0333102414566860

Source DB:  PubMed          Journal:  Cephalalgia        ISSN: 0333-1024            Impact factor:   6.292


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