Yi Chen1, Cheng-Jie Mao1, Si-Jiao Li1, Fen Wang2, Jing Chen1, Hui-Jun Zhang1, Ling Li1, Sha-Sha Guo1, Ya-Ping Yang3, Chun-Feng Liu4. 1. Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China. 2. Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, Suzhou 215123, China. 3. Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, Suzhou 215123, China; Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China. 4. Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, Suzhou 215123, China; Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China. Electronic address: liucf@suda.edu.cn.
Abstract
INTRODUCTION: Pain and sensory disturbances affect many patients with Parkinson's disease (PD). The present study aimed to evaluate the pain and sensory sensitivity of each class of afferent fibers in PD patients and determine the effects of dopaminergic therapy on pain and sensory sensitivity. METHODS: Current perception threshold (CPT) and pain tolerance thresholds (PTT) at three frequencies, 2000 Hz, 250 Hz, and 5 Hz, to stimulate Aβ fibers, Aδ fibers, and small C-polymodal fibers, respectively, were measured in 72 PD patients and 35 healthy controls. RESULTS: CPT was higher at all three frequencies and PTT was lower at 2000 Hz and 250 Hz in PD patients with pain versus healthy controls (P < 0.05). CPT was higher at 2000 Hz and 250 Hz and PTT was lower at 2000 Hz and 250 Hz in PD patients without pain versus healthy controls (P < 0.05). PD patients with pain exhibited higher CPT at 5 Hz and 250 Hz than PD patients without pain (P < 0.05). Dopaminergic therapy did not affect CPT or PPT in PD patients (P > 0.05). CONCLUSIONS: Abnormal Aδ fiber- and Aβ fiber-dependent sensory inputs may exist in PD. Abnormal sensory inputs via C fibers and Aδ fibers might be associated with the presence of pain in PD. Because dopaminergic therapy failed to mitigate these sensory and pain dysfunctions, mechanisms not involving the dopaminergic pathway are likely to be implicated.
INTRODUCTION:Pain and sensory disturbances affect many patients with Parkinson's disease (PD). The present study aimed to evaluate the pain and sensory sensitivity of each class of afferent fibers in PDpatients and determine the effects of dopaminergic therapy on pain and sensory sensitivity. METHODS: Current perception threshold (CPT) and pain tolerance thresholds (PTT) at three frequencies, 2000 Hz, 250 Hz, and 5 Hz, to stimulate Aβ fibers, Aδ fibers, and small C-polymodal fibers, respectively, were measured in 72 PDpatients and 35 healthy controls. RESULTS: CPT was higher at all three frequencies and PTT was lower at 2000 Hz and 250 Hz in PDpatients with pain versus healthy controls (P < 0.05). CPT was higher at 2000 Hz and 250 Hz and PTT was lower at 2000 Hz and 250 Hz in PDpatients without pain versus healthy controls (P < 0.05). PDpatients with pain exhibited higher CPT at 5 Hz and 250 Hz than PDpatients without pain (P < 0.05). Dopaminergic therapy did not affect CPT or PPT in PDpatients (P > 0.05). CONCLUSIONS: Abnormal Aδ fiber- and Aβ fiber-dependent sensory inputs may exist in PD. Abnormal sensory inputs via C fibers and Aδ fibers might be associated with the presence of pain in PD. Because dopaminergic therapy failed to mitigate these sensory and pain dysfunctions, mechanisms not involving the dopaminergic pathway are likely to be implicated.
Authors: G C Nascimento; K Bariotto-Dos-Santos; C R A Leite-Panissi; E A Del-Bel; M Bortolanza Journal: Neurotox Res Date: 2018-04-02 Impact factor: 3.911