| Literature DB >> 25629320 |
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Abstract
Entities:
Year: 2015 PMID: 25629320 PMCID: PMC4309675 DOI: 10.1371/journal.pone.0117632
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Association of genetic variants in BCL-2-family genes with endometrial cancer risk among 1,028 cases and 1,922 controls, the Shanghai Endometrial Cancer Genetics Study (SECGS).
| Gene/chromosome | Heterozygous (Aa) | Homozygous for minor allele (aa) | ||||
|---|---|---|---|---|---|---|
| SNP ( | Allelesa | Gene region | MAFb | OR (95% CI) | OR (95% CI) |
|
|
| ||||||
| rs1009726 | C/G | 5UTR | 0.191 | 1.08 (0.92–1.28) | 1.05 (0.67–1.64) | 0.41 |
| rs10503077 | C/T | 5UTR | 0.038 | 1.05 (0.78–1.40) | 3.88 (0.35–43.7) | 0.56 |
| rs10503078 | G/A | 5UTR | 0.378 | 0.99 (0.83–1.17) | 0.96 (0.75–1.22) | 0.80 |
| rs11152370 | G/C | 5UTR | 0.117 | 0.98 (0.81–1.19) | 0.66 (0.32–1.34) | 0.48 |
| rs11152374 | G/A | 3UTR | 0.257 | 1.09 (0.92–1.28) | 1.24 (0.92–1.69) | 0.12 |
| rs11659758 | T/A | 5UTR | 0.193 | 1.00 (0.84–1.18) | 0.78 (0.50–1.22) | 0.52 |
| rs11872329 | C/T | 5UTR | 0.037 | 1.22 (0.91–1.63) | 1.96 (0.45–8.59) | 0.13 |
| rs11877911 | C/G | 5UTR | 0.095 | 0.99 (0.80–1.22) | 0.94 (0.42–2.08) | 0.91 |
| rs12454712 | T/C | 5UTR | 0.446 | 0.95 (0.79–1.17) | 0.94 (0.75–1.17) | 0.74 |
| rs12457190 | G/A | 5UTR | 0.354 | 0.95 (0.80–1.12) | 1.03 (0.84–1.33) | 0.94 |
| rs12457831 | G/C | 5UTR | 0.359 | 0.97 (0.82–1.15) | 1.03 (0.79–1.32) | 0.97 |
| rs12457893 | C/A | 3UTR | 0.384 | 0.96 (0.81–1.13) | 1.07 (0.84–1.34) | 0.82 |
| rs12605881 | A/T | 3UTR | 0.344 | 0.93 (0.78–1.09) | 1.05 (0.82–1.34) | 0.92 |
| rs12961672 | G/C | 5UTR | 0.191 | 0.99 (0.84–1.17) | 0.87 (0.56–1.37) | 0.69 |
|
| C/T | 3UTR | 0.182 | 1.16 (0.97–1.38) | 1.30 (0.93–1.82) |
|
| rs12963776 | G/A | 5UTR | 0.393 | 0.99 (0.84–1.18) | 1.02 (0.80–1.30) | 0.90 |
| rs12967026 | C/G | 5UTR | 0.38 | 1.16 (0.98–1.38) | 1.13 (0.89–1.44) | 0.16 |
| rs1381547 | T/C | 3UTR | 0.384 | 1.14 (0.96–1.35) | 0.94 (0.75–1.19) | 0.99 |
| rs1381548 | G/A | 3UTR | 0.266 | 0.94 (0.80–1.11) | 0.75 (0.53–1.05) | 0.12 |
| rs1531697 | T/A | 5UTR | 0.404 | 0.98 (0.82–1.16) | 1.03 (0.81–1.30) | 0.93 |
| rs17070739 | T/G | 5UTR | 0.227 | 1.03 (0.88–1.22) | 1.15 (0.79–1.69) | 0.46 |
| rs17070809 | G/A | 5UTR | 0.32 | 1.03 (0.88–1.21) | 0.91 (0.69–1.20) | 0.79 |
| rs17070904 | C/T | 3UTR | 0.088 | 0.96 (0.78–1.19) | 0.69 (0.27–1.79) | 0.54 |
|
| A/G | 3UTR | 0.101 | 1.27 (1.04–1.53) | 1.16 (0.53–2.53) |
|
| rs17841945 | G/A | 5UTR | 0.125 | 0.87 (0.71–1.05) | 0.77 (0.40–1.47) | 0.11 |
| rs1944419 | T/A | 3UTR | 0.409 | 0.91 (0.77–1.08) | 1.01 (0.80–1.26) | 0.81 |
| rs1944421 | T/C | 3UTR | 0.131 | 0.96 (0.80–1.16) | 1.33 (0.76–2.33) | 0.88 |
| rs1944423 | A/G | Promotor | 0.379 | 1.12 (0.95–1.33) | 1.24 (0.97–1.57) | 0.07 |
| rs1982673 | A/C | 5UTR | 0.435 | 0.92 (0.77–1.10) | 1.03 (0.82–1.29) | 0.98 |
| rs2046135 | T/A | 5UTR | 0.168 | 1.09 (0.92–1.29) | 0.94 (0.55–1.60) | 0.49 |
|
| C/A | Intron | 0.344 | 0.95 (0.81–1.12) | 0.73 (0.56–0.95) |
|
| rs2199937 | T/C | 5UTR | 0.489 | 1.08 (0.90–1.31) | 1.13 (0.91–1.41) | 0.28 |
| rs2279115 | G/T | Promotor | 0.378 | 1.13 (0.95–1.34) | 1.19 (0.94–1.52) | 0.09 |
| rs2849382 | A/G | 3UTR | 0.233 | 0.93 (0.79–1.10) | 1.14 (0.81–1.62) | 0.92 |
| rs2850755 | A/G | 3UTR | 0.101 | 0.99 (0.81–1.22) | 0.62 (0.26–1.50) | 0.60 |
| rs2850758 | T/C | 3UTR | 0.1 | 1.00 (0.81–1.23) | 0.63 (0.26–1.50) | 0.65 |
| rs3744933 | G/T | 5UTR | 0.076 | 0.97 (0.77–1.21) | 2.14 (0.91–5.05) | 0.61 |
| rs3744951 | T/C | 3UTR | 0.045 | 1.13 (0.87–1.48) | 2.42 (0.21–28.1) | 0.29 |
| rs4941183 | A/G | 5UTR | 0.405 | 0.90 (0.76–1.07) | 0.97 (0.76–1.23) | 0.50 |
| rs4941185 | G/A | 5UTR | 0.483 | 1.02 (0.84–1.23) | 1.02 (0.82–1.28) | 0.89 |
| rs4941188 | A/G | 5UTR | 0.39 | 0.98 (0.83–1.16) | 0.97 (0.77–1.24) | 0.79 |
| rs4941190 | A/G | 3UTR | 0.103 | 1.08 (0.89–1.32) | 1.39 (0.62–3.13) | 0.30 |
| rs4941192 | A/G | 3UTR | 0.072 | 1.07 (0.86–1.34) | 2.20 (0.67–7.19) | 0.32 |
|
| A/C | 3UTR | 0.226 | 1.28 (1.09–1.50) | 1.06 (0.74–1.52) |
|
| rs4987716 | C/A | 3UTR | 0.076 | 1.08 (0.87–1.35) | 1.07 (0.43–2.64) | 0.49 |
| rs4987721 | T/C | 3UTR | 0.177 | 0.88 (0.74–1.04) | 1.27 (0.82–1.99) | 0.54 |
| rs4987739 | C/T | 3UTR | 0.055 | 1.23 (0.97–1.57) | 1.14 (0.15–8.37) | 0.09 |
|
| C/A | 3UTR | 0.295 | 1.16 (0.98–1.37) | 1.32 (1.00–1.73) |
|
| rs4987808 | G/T | 5UTR | 0.088 | 0.96 (0.77–1.19) | 0.58 (0.21–1.64) | 0.45 |
| rs4987839 | T/C | 5UTR | 0.397 | 0.93 (0.78–1.10) | 0.99 (0.78–1.25) | 0.70 |
| rs6567326 | G/T | 5UTR | 0.474 | 0.96 (0.80–1.15) | 0.87 (0.70–1.09) | 0.22 |
| rs6567328 | A/G | 5UTR | 0.356 | 0.91 (0.77–1.07) | 0.93 (0.72–1.19) | 0.33 |
| rs6567334 | A/C | 3UTR | 0.444 | 1.03 (0.86–1.23) | 1.24 (1.00–1.54) | 0.07 |
| rs720321 | G/A | 5UTR | 0.145 | 1.16 (0.98–1.37) | N/A | 0.37 |
| rs7226979 | T/C | 3UTR | 0.456 | 0.94 (0.78–1.12) | 1.04 (0.84–1.29) | 0.83 |
|
| C/T | 5UTR | 0.323 | 0.91 (0.77–1.07) | 0.68 (0.51–0.90) |
|
| rs7230970 | T/C | 5UTR | 0.255 | 1.02 (0.87–1.20) | 1.18 (0.85–1.65) | 0.44 |
|
| A/C | 3UTR | 0.327 | 0.92 (0.78–1.08) | 0.69 (0.52–0.91) |
|
| rs7236090 | T/C | 3UTR | 0.415 | 0.92 (0.77–1.09) | 1.18 (0.95–1.48) | 0.28 |
| rs7240319 | A/G | 5UTR | 0.165 | 0.87 (0.73–1.04) | 0.96 (0.58–1.60) | 0.17 |
| rs7240326 | T/C | 3UTR | 0.24 | 0.95 (0.80–1.12) | 0.87 (0.61–1.25) | 0.38 |
|
| G/A | 5UTR | 0.183 | 1.16 (0.98–1.37) | 1.82 (1.21–2.73) |
|
| rs7243985 | C/T | Promotor | 0.265 | 0.96 (0.81–1.13) | 1.04 (0.77–1.41) | 0.90 |
| rs8083946 | A/G | 3UTR | 0.36 | 1.00 (0.85–1.18) | 0.92 (0.71–1.19) | 0.63 |
| rs8084922 | C/G | 3UTR | 0.338 | 0.89 (0.76–1.05) | 1.07 (0.83–1.38) | 0.86 |
| rs8089331 | C/G | 3UTR | 0.24 | 0.97 (0.82–1.14) | 1.01 (0.72–1.40) | 0.81 |
| rs8094651 | C/A | 5UTR | 0.493 | 0.95 (0.79–1.14) | 0.87 (0.70–1.08) | 0.20 |
| rs8096471 | G/A | 3UTR | 0.157 | 0.90 (0.75–1.08) | 1.31 (0.81–2.13) | 0.74 |
| rs954954 | A/C | Intron | 0.161 | 1.16 (0.97–1.37) | 1.15 (0.69–1.92) | 0.10 |
|
| T/A | 3UTR | 0.345 | 0.94 (0.80–1.11) | 0.73 (0.56–0.95) |
|
| rs9955190 | A/G | 5UTR | 0.233 | 0.97 (0.83–1.15) | 1.11 (0.78–1.58) | 0.91 |
| rs9965844 | G/C | 5UTR | 0.078 | 1.00 (0.80–1.25) | 1.71 (0.71–4.11) | 0.61 |
|
| ||||||
| rs660442 | G/A | 5UTR | 0.066 | 1.13 (0.89–1.42) | 0.20 (0.02–1.59) | 0.69 |
| rs1468558 | G/A | 5UTR | 0.073 | 0.91 (0.72–1.15) | 0.26 (0.06–1.19) | 0.16 |
| rs671976 | A/G | Intron | 0.347 | 0.86 (0.73–1.01) | 1.17 (0.91–1.49) | 0.84 |
| rs477895 | T/C | 3UTR | 0.233 | 0.91 (0.77–1.08) | 0.85 (0.59–1.21) | 0.18 |
|
| ||||||
| rs11667229 | T/C | Promotor | 0.385 | 1.15 (0.97–1.36) | 0.97 (0.76–1.23) | 0.79 |
| rs11667351 | T/G | Promotor | 0.067 | 1.06 (0.84–1.33) | 0.14 (0.02–1.12) | 0.77 |
| rs1805419 | G/A | Intron | 0.375 | 1.00 (0.85–1.19) | 0.96 (0.74–1.23) | 0.93 |
| rs8108882 | T/C | 3UTR | 0.47 | 0.98 (0.82–1.18) | 1.04 (0.84–1.30) | 0.73 |
| rs905238 | A/G | 3UTR | 0.355 | 0.93 (0.78–1.09) | 1.05 (0.81–1.34) | 0.88 |
|
| ||||||
| rs210132 | G/T | 3UTR | 0.387 | 1.01 (0.85–1.19) | 0.90 (0.71–1.15) | 0.51 |
| rs210134 | G/A | 3UTR | 0.26 | 1.01 (0.86–1.19) | 1.05 (0.77–1.43) | 0.78 |
| rs210139 | C/A | Intron | 0.308 | 1.13 (0.96–1.33) | 1.01 (0.77–1.33) | 0.46 |
| rs563751 | A/G | 3UTR | 0.471 | 1.07 (0.89–1.29) | 0.93 (0.74–1.15) | 0.52 |
| rs5745577 | C/T | Intron | 0.039 | 1.04 (0.78–1.39) | 1.00 (0.09–11.4) | 0.80 |