OBJECTIVE: To evaluate the type-specific human papillomavirus (HPV) persistence or regression in women with or less than low-grade cervical intraepithelial neoplasia (CIN). METHODS: This prospective cohort study included patients with or less than cytological low-grade squamous intraepithelial lesion (or histologically CIN 1 when biopsy was performed) combined with HPV infection. The cohort was collected from July 2006 to November 2011 at Korea University Guro Hospital. Follow-up was performed with liquid-based Papanicolaou test, hybrid capture 2 test, AnyplexTM II HPV 28 Detection, colposcopic biopsy if necessary every 4 months. All patients were prospectively observed without treatment. RESULTS: One hundred and thirty-seven patients were enrolled. Of these, 21 patients whose minimum follow-up periods were less than 8 months were excluded. Finally, one hundred sixteen patients were included and followed-up. Median follow-up period was 16 months. In case of high-risk HPVs, HPV 53 was the most prevalent type, followed by HPV 52, 68, 66, and 16. HPV 16 took 10.6 months to regress spontaneously, which was the longest period among the 10 most prevalent high-risk HPV genotypes. In case of spontaneous regression, HPV clearance was always accompanied by lesion clearance. A total of 13 patients showed disease progression either cytologically or histologically. Two cases of CIN 3 were confirmed by colposcopy-directed biopsy during follow-up, which were subsequently managed by conization. CONCLUSION: HPV 16 is the most persistent HPV genotypes. Studies with longer term follow-up and larger sample size are needed to demonstrate whether persistence of HPV 16 is directly correlated with progression of low-grade lesions.
OBJECTIVE: To evaluate the type-specific human papillomavirus (HPV) persistence or regression in women with or less than low-grade cervical intraepithelial neoplasia (CIN). METHODS: This prospective cohort study included patients with or less than cytological low-grade squamous intraepithelial lesion (or histologically CIN 1 when biopsy was performed) combined with HPV infection. The cohort was collected from July 2006 to November 2011 at Korea University Guro Hospital. Follow-up was performed with liquid-based Papanicolaou test, hybrid capture 2 test, AnyplexTM II HPV 28 Detection, colposcopic biopsy if necessary every 4 months. All patients were prospectively observed without treatment. RESULTS: One hundred and thirty-seven patients were enrolled. Of these, 21 patients whose minimum follow-up periods were less than 8 months were excluded. Finally, one hundred sixteen patients were included and followed-up. Median follow-up period was 16 months. In case of high-risk HPVs, HPV 53 was the most prevalent type, followed by HPV 52, 68, 66, and 16. HPV 16 took 10.6 months to regress spontaneously, which was the longest period among the 10 most prevalent high-risk HPV genotypes. In case of spontaneous regression, HPV clearance was always accompanied by lesion clearance. A total of 13 patients showed disease progression either cytologically or histologically. Two cases of CIN 3 were confirmed by colposcopy-directed biopsy during follow-up, which were subsequently managed by conization. CONCLUSION:HPV 16 is the most persistent HPV genotypes. Studies with longer term follow-up and larger sample size are needed to demonstrate whether persistence of HPV 16 is directly correlated with progression of low-grade lesions.
Entities:
Keywords:
Cervical intraepithelial neoplasia; Genotype; Human papillomavirus
Authors: Anna-Barbara Moscicki; Stephen Shiboski; Nancy K Hills; Kimberly J Powell; Naomi Jay; Evelyn N Hanson; Susanna Miller; K Lisa Canjura-Clayton; Sepidah Farhat; Jeanette M Broering; Teresa M Darragh Journal: Lancet Date: 2004 Nov 6-12 Impact factor: 79.321
Authors: Harriet Richardson; Gail Kelsall; Pierre Tellier; Hélène Voyer; Michal Abrahamowicz; Alex Ferenczy; François Coutlée; Eduardo L Franco Journal: Cancer Epidemiol Biomarkers Prev Date: 2003-06 Impact factor: 4.254
Authors: Kyeong A So; Seon Ah Kim; Yoo Kyung Lee; In Ho Lee; Ki Heon Lee; Jee Eun Rhee; Mee Kyung Kee; Chi Heum Cho; Sung Ran Hong; Chang Sun Hwang; Mi Seon Jeong; Ki Tae Kim; Moran Ki; Soo Young Hur; Jong Sup Park; Tae Jin Kim Journal: Obstet Gynecol Sci Date: 2018-10-15
Authors: Wieke W Kremer; Johannes Berkhof; Maaike Cg Bleeker; Daniëlle Am Heideman; Nienke E van Trommel; Marchien W van Baal; Harold R Verhoeve; Chris Jlm Meijer; Gemma G Kenter Journal: BMJ Open Date: 2019-07-09 Impact factor: 2.692
Authors: Luisa Del Río-Ospina; Milena Camargo; Sara C Soto-De León; Ricardo Sánchez; Darwin A Moreno-Pérez; Manuel E Patarroyo; Manuel A Patarroyo Journal: Sci Rep Date: 2020-04-29 Impact factor: 4.379
Authors: Shuying Dai; Chuanyin Li; Zhiling Yan; Ziyun Zhou; Xia Wang; Jun Wang; Le Sun; Li Shi; Yufeng Yao Journal: Int J Med Sci Date: 2020-03-26 Impact factor: 3.738