| Literature DB >> 2562852 |
D A Walsh1, S K Franzyshen, J M Yanni.
Abstract
A series of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines was synthesized and evaluated for antiallergy activity. Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity. In particular 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.Entities:
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Year: 1989 PMID： 2562852 DOI： 10.1021/jm00121a022
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446