Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.

Literature DB >> 25628398

Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.

Jean-Charles Nault¹, Augusto Villanueva².

Abstract

Hepatocellular carcinoma is a highly heterogeneous disease both at the molecular and clinical levels. Intratumor morphologic and genetic heterogeneity adds a new level of complexity in our understanding of liver carcinogenesis, and it is likely an important determinant of primary and secondary resistance to targeted therapies. Clin Cancer Res; 21(8); 1786-8. ©2015 AACR. See related article by Friemel et al., p. 1951. ©2015 American Association for Cancer Research.

Entities: Disease

Mesh：

Year: 2015 PMID： 25628398 DOI： 10.1158/1078-0432.CCR-14-2602

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

Keyword Cloud
Cited

42 in total

1. Truncated neurokinin-1 receptor is an ubiquitous antitumor target in hepatoblastoma, and its expression is independent of tumor biology and stage.

Authors: Agnès Garnier; Matthias Ilmer; Kristina Becker; Beate Häberle; Dietrich VON Schweinitz; Roland Kappler; Michael Berger
Journal: Oncol Lett Date: 2015-11-20 Impact factor: 2.967

2. MicroRNA-129-5p promotes proliferation and metastasis of hepatocellular carcinoma by regulating the BMP2 gene.

Authors: Zengyao Liu; Jiefei Sun; Xiaochun Wang; Zhenyuan Cao
Journal: Exp Ther Med Date: 2021-01-25 Impact factor: 2.447

3. m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma.

Authors: Dongkai Zhou; Yizhi Wang; Wei Wei; Wei Zhou; Jin Gu; Yang Kong; Qifan Yang; Yingsheng Wu
Journal: J Cancer Res Clin Oncol Date: 2022-08-16 Impact factor: 4.322

4. High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma.

Authors: Xi Chen; Letao Lin; Guanyu Chen; Huzheng Yan; Zhenyu Li; Meigui Xiao; Xu He; Fujun Zhang; Yanling Zhang
Journal: Front Oncol Date: 2022-06-22 Impact factor: 5.738

Review 5. Tumour evolution in hepatocellular carcinoma.

Authors: Amanda J Craig; Johann von Felden; Teresa Garcia-Lezana; Samantha Sarcognato; Augusto Villanueva
Journal: Nat Rev Gastroenterol Hepatol Date: 2019-12-02 Impact factor: 46.802

6. Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.

Authors: Pedro Molina-Sánchez; Marina Ruiz de Galarreta; Melissa A Yao; Katherine E Lindblad; Erin Bresnahan; Elizabeth Bitterman; Tiphaine C Martin; Troy Rubenstein; Kai Nie; Jonathan Golas; Shambhunath Choudhary; Marina Bárcena-Varela; Abdulkadir Elmas; Veronica Miguela; Ying Ding; Zhengyan Kan; Lauren Tal Grinspan; Kuan-Lin Huang; Ramon E Parsons; David J Shields; Robert A Rollins; Amaia Lujambio
Journal: Gastroenterology Date: 2020-08-16 Impact factor: 22.682

Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.

1. Truncated neurokinin-1 receptor is an ubiquitous antitumor target in hepatoblastoma, and its expression is independent of tumor biology and stage.

2. MicroRNA-129-5p promotes proliferation and metastasis of hepatocellular carcinoma by regulating the BMP2 gene.

3. m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma.

4. High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma.

Review 5. Tumour evolution in hepatocellular carcinoma.

6. Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.

Review 7. Proteoglycans in Cancer: Friends or Enemies? A Special Focus on Hepatocellular Carcinoma.

8. Prognostic value of DNA repair based stratification of hepatocellular carcinoma.

Review 9. The Endless Sources of Hepatocellular Carcinoma Heterogeneity.

10. A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.