Literature DB >> 25628326

Is time of the essence? Delayed diagnosis of Ewing's sarcoma.

Madeline Edwards1, Jacqueline Halton1, Raveena Ramphal1, Donna Johnston1.   

Abstract

Rarely in modern medicine are we able to observe the natural history of a patient with a sarcoma. This unusual case provides that opportunity. A CT scan was performed on the leg of a 15-year-old boy with a tender soft tissue mass on the lateral aspect of his left calf. Despite showing a lesion consistent with a sarcoma, neither the patient nor his family was informed. Almost a year and a half later, the patient returned and was diagnosed with Ewing's sarcoma. A staging work up showed no metastatic disease. After undergoing chemotherapy and a complete surgical resection of the tumour, the patient remains disease-free 10 years later, indicating that the biology of Ewing's sarcoma may be more important than time to diagnosis in determining outcome. 2015 BMJ Publishing Group Ltd.

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Mesh:

Year:  2015        PMID: 25628326      PMCID: PMC4322250          DOI: 10.1136/bcr-2014-208307

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  11 in total

1.  Ewing's sarcoma family tumours. Differences in clinicopathological characteristics at presentation between localised and metastatic tumours.

Authors:  G Bacci; A Balladelli; C Forni; A Longhi; M Serra; N Fabbri; M Alberghini; S Ferrari; M S Benassi; P Picci
Journal:  J Bone Joint Surg Br       Date:  2007-09

2.  Time to diagnosis of Ewing tumors in children and adolescents is not associated with metastasis or survival: a prospective multicenter study of 436 patients.

Authors:  Jean-François Brasme; Martin Chalumeau; Odile Oberlin; Dominique Valteau-Couanet; Nathalie Gaspar
Journal:  J Clin Oncol       Date:  2014-05-19       Impact factor: 44.544

3.  Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.

Authors:  Ruth Ladenstein; Ulrike Pötschger; Marie Cécile Le Deley; Jeremy Whelan; Michael Paulussen; Odile Oberlin; Henk van den Berg; Uta Dirksen; Lars Hjorth; Jean Michon; Ian Lewis; Alan Craft; Heribert Jürgens
Journal:  J Clin Oncol       Date:  2010-06-14       Impact factor: 44.544

Review 4.  Epidemiology of childhood cancer.

Authors:  Peter Kaatsch
Journal:  Cancer Treat Rev       Date:  2010-03-15       Impact factor: 12.111

5.  Delay in diagnosis of children with cancer: a retrospective study of 315 children.

Authors:  M Haimi; M Peretz Nahum; M Weyl Ben Arush
Journal:  Pediatr Hematol Oncol       Date:  2004 Jan-Feb       Impact factor: 1.969

Review 6.  Soft tissue tumors associated with EWSR1 translocation.

Authors:  Salvatore Romeo; Angelo P Dei Tos
Journal:  Virchows Arch       Date:  2010-02       Impact factor: 4.064

7.  Symptom interval in young people with bone cancer.

Authors:  S Goyal; J Roscoe; W D J Ryder; H R Gattamaneni; T O B Eden
Journal:  Eur J Cancer       Date:  2004-10       Impact factor: 9.162

8.  Interval between symptom onset and diagnosis of pediatric solid tumors.

Authors:  B H Pollock; J P Krischer; T J Vietti
Journal:  J Pediatr       Date:  1991-11       Impact factor: 4.406

Review 9.  Diagnosis delays in childhood cancer: a review.

Authors:  Tam Dang-Tan; Eduardo L Franco
Journal:  Cancer       Date:  2007-08-15       Impact factor: 6.860

10.  Prognostic factors in localized Ewing's tumours and peripheral neuroectodermal tumours: the third study of the French Society of Paediatric Oncology (EW88 study).

Authors:  O Oberlin; M C Deley; B N Bui; J C Gentet; T Philip; P Terrier; C Carrie; F Mechinaud; C Schmitt; A Babin-Boillettot; J Michon
Journal:  Br J Cancer       Date:  2001-11-30       Impact factor: 7.640

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  1 in total

Review 1.  Molecular mechanisms underpinning sarcomas and implications for current and future therapy.

Authors:  Victoria Damerell; Michael S Pepper; Sharon Prince
Journal:  Signal Transduct Target Ther       Date:  2021-06-30
  1 in total

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