Literature DB >> 25628068

The structure of clinical translation: efficiency, information, and ethics.

Jonathan Kimmelman, Alex John London.   

Abstract

The so-called drug pipeline is not really about drugs and not much like a pipeline. It is really about the production and dissemination of information, and it is much more like a web. The misunderstanding leads to a poor understanding of what's wrong with clinical translation and how it can be improved.

Mesh：

Substances：

Year:  2015        PMID： 25628068     DOI： 10.1002/hast.433

Source DB:  PubMed          Journal:  Hastings Cent Rep        ISSN： 0093-0334            Impact factor:   2.683


  14 in total

Review 1.  Pharmacovigilance as Scientific Discovery: An Argument for Trans-Disciplinarity.

Authors:  Elena Rocca; Samantha Copeland; I Ralph Edwards
Journal:  Drug Saf       Date:  2019-10       Impact factor: 5.606

2.  Mapping the Ethics of Translational Genomics: Situating Return of Results and Navigating the Research-Clinical Divide.

Authors:  Susan M Wolf; Wylie Burke; Barbara A Koenig
Journal:  J Law Med Ethics       Date:  2015       Impact factor: 1.718

Review 3.  Is Participation in Cancer Phase I Trials Really Therapeutic?

Authors:  Jonathan Kimmelman
Journal:  J Clin Oncol       Date:  2016-09-30       Impact factor: 44.544

4.  Stakeholder views on participant selection for first-in-human trials in cancer nanomedicine.

Authors:  P Satalkar; B S Elger; D M Shaw
Journal:  Curr Oncol       Date:  2016-12-21       Impact factor: 3.677

Review 5.  Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib.

Authors:  Benjamin Carlisle; Nadine Demko; Georgina Freeman; Amanda Hakala; Nathalie MacKinnon; Tim Ramsay; Spencer Hey; Alex John London; Jonathan Kimmelman
Journal:  J Natl Cancer Inst       Date:  2015-11-07       Impact factor: 13.506

Review 6.  Sunitinib Possible Sex-Divergent Therapeutic Outcomes.

Authors:  Ignacio Segarra; Pilar Modamio; Cecilia Fernández; Eduardo L Mariño
Journal:  Clin Drug Investig       Date:  2016-10       Impact factor: 2.859

7.  Perspectives About Time Frames in Stem Cell Research for Multiple Sclerosis: "Time Is Brain".

Authors:  Shelly Benjaminy; Cody Lo; Andrew Schepmyer; Anthony Traboulsee; Judy Illes
Journal:  Int J MS Care       Date:  2019 Jul-Aug

8.  Tackling Ethical Challenges of Premature Delivery of Stem Cell-Based Therapies: ISSCR 2018 Annual Meeting Focus Session Report.

Authors:  Jeremy Sugarman; Roger A Barker; Ian Kerridge; Tamra Lysaght; Graziella Pellegrini; Douglas Sipp; Claire Tanner
Journal:  Stem Cell Reports       Date:  2018-11-13       Impact factor: 7.765

Review 9.  Ethically designing research to inform multidimensional, rapidly evolving policy decisions: Lessons learned from the PROMISE HIV Perinatal Prevention Trial.

Authors:  Seema K Shah; Alex John London; Lynne Mofenson; James V Lavery; Grace John-Stewart; Patricia Flynn; Gerhard Theron; Shrikhant I Bangdiwala; Dhayendre Moodley; Lameck Chinula; Lee Fairlie; Tumalano Sekoto; Tebogo J Kakhu; Avy Violari; Sufia Dadabhai; Katie McCarthy; Mary Glenn Fowler
Journal:  Clin Trials       Date:  2021-09-15       Impact factor: 2.599

10.  Using the concept of "deserved trust" to strengthen the value and integrity of biomedical research.

Authors:  Mark Yarborough
Journal:  Account Res       Date:  2020-12-26       Impact factor: 3.057
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.