Giuseppe Minniti1, Claudia Scaringi2, Maurizio Poggi2, Marie Lise Jaffrain Rea2, Giuseppe Trillò2, Vincenzo Esposito2, Alessandro Bozzao2, Maurizio Maurizi Enrici2, Vincenzo Toscano2, Riccardo Maurizi Enrici2. 1. Radiation Oncology UnitSant' Andrea Hospital, University Sapienza, Via di Grottarossa 1035, 00189 Rome, ItalyIRCCS NeuromedPozzilli, Isernia, ItalyEndocrinology UnitNeurosurgery UnitNeuroradiology UnitOphthalmology UnitSant' Andrea Hospital, University Sapienza, Rome, Italy Radiation Oncology UnitSant' Andrea Hospital, University Sapienza, Via di Grottarossa 1035, 00189 Rome, ItalyIRCCS NeuromedPozzilli, Isernia, ItalyEndocrinology UnitNeurosurgery UnitNeuroradiology UnitOphthalmology UnitSant' Andrea Hospital, University Sapienza, Rome, Italy gminniti@ospedalesantandrea.it. 2. Radiation Oncology UnitSant' Andrea Hospital, University Sapienza, Via di Grottarossa 1035, 00189 Rome, ItalyIRCCS NeuromedPozzilli, Isernia, ItalyEndocrinology UnitNeurosurgery UnitNeuroradiology UnitOphthalmology UnitSant' Andrea Hospital, University Sapienza, Rome, Italy.
Abstract
OBJECTIVE: We describe the use of fractionated stereotactic radiotherapy (FSRT) for the treatment of large, invasive, nonfunctioning pituitary adenomas (NFPAs). FSRT is frequently employed for the treatment of residual or recurrent pituitary adenomas. PATIENTS AND METHODS: Sixty-eight patients with a large residual or recurrent NFPAs were treated between April 2004 and December 2012, including 39 males and 29 females (median age 51 years). Visual defects were present in 34 patients, consisting of visual field defects (n=31) and/or reduced visual acuity (n=12). Forty-five patients had evidence of partial or total hypopituitarism before FSRT. For most of the patients, the treatment was delivered through 5-10 noncoplanar conformal fixed fields using a 6-MV linear accelerator to a dose of 45 Gy in 25 fractions. RESULTS: At a median follow-up of 75 months (range 12-120 months), the 5- and 10-year actuarial local control were 97 and 91%, respectively, and overall survival 97 and 93%, respectively. Forty-nine patients had a tumor reduction, 16 remained stable, and three progressed. The relative tumor volume reduction measured using three-dimensional (3D) magnetic resonance imaging (MRI) was 47%. The treatment was well tolerated with minimal acute toxicity. Eighteen patients developed partial or complete hypopituitarism. The actuarial incidence of new anterior pituitary deficits was 40% at 5 years and 72% at 10 years. No other radiation-induced complications occurred. CONCLUSIONS: Our results suggest that FSRT is an effective treatment for large or giant pituitary adenomas with low toxicity.
OBJECTIVE: We describe the use of fractionated stereotactic radiotherapy (FSRT) for the treatment of large, invasive, nonfunctioning pituitary adenomas (NFPAs). FSRT is frequently employed for the treatment of residual or recurrent pituitary adenomas. PATIENTS AND METHODS: Sixty-eight patients with a large residual or recurrent NFPAs were treated between April 2004 and December 2012, including 39 males and 29 females (median age 51 years). Visual defects were present in 34 patients, consisting of visual field defects (n=31) and/or reduced visual acuity (n=12). Forty-five patients had evidence of partial or total hypopituitarism before FSRT. For most of the patients, the treatment was delivered through 5-10 noncoplanar conformal fixed fields using a 6-MV linear accelerator to a dose of 45 Gy in 25 fractions. RESULTS: At a median follow-up of 75 months (range 12-120 months), the 5- and 10-year actuarial local control were 97 and 91%, respectively, and overall survival 97 and 93%, respectively. Forty-nine patients had a tumor reduction, 16 remained stable, and three progressed. The relative tumor volume reduction measured using three-dimensional (3D) magnetic resonance imaging (MRI) was 47%. The treatment was well tolerated with minimal acute toxicity. Eighteen patients developed partial or complete hypopituitarism. The actuarial incidence of new anterior pituitary deficits was 40% at 5 years and 72% at 10 years. No other radiation-induced complications occurred. CONCLUSIONS: Our results suggest that FSRT is an effective treatment for large or giant pituitary adenomas with low toxicity.
Authors: I Jonathan Pomeraniec; Hideyuki Kano; Zhiyuan Xu; Brandon Nguyen; Zaid A Siddiqui; Danilo Silva; Mayur Sharma; Hesham Radwan; Jonathan A Cohen; Robert F Dallapiazza; Christian Iorio-Morin; Amparo Wolf; John A Jane; Inga S Grills; David Mathieu; Douglas Kondziolka; Cheng-Chia Lee; Chih-Chun Wu; Christopher P Cifarelli; Tomas Chytka; Gene H Barnett; L Dade Lunsford; Jason P Sheehan Journal: J Neurosurg Date: 2017-10-27 Impact factor: 5.115
Authors: Michael W O'Reilly; Raoul C Reulen; Saket Gupta; Claire A Thompson; Rosemary Dineen; Eirena L Goulden; Gabriella Bugg; Harriet Pearce; Andy A Toogood; Neil J Gittoes; Rosalind Mitchell; Christopher J Thompson; John Ayuk Journal: Clin Endocrinol (Oxf) Date: 2016-07-25 Impact factor: 3.478