J Saleh-Langenberg1,2, N J Goossens1,2, B M J Flokstra-de Blok2,3, B J Kollen2, G N van der Meulen1,4, T M Le5, A C Knulst5, M Jedrzejczak-Czechowicz6, M L Kowalski6, E Rokicka7, P Starosta7, B de la Hoz Caballer8, S Vazquez-Cortés9, I Cerecedo8, L Barreales10, R Asero11, M Clausen12, A DunnGalvin13, J O' B Hourihane13, A Purohit14, N G Papadopoulos15,16, M Fernandéz-Rivas9, L Frewer17,18, P Burney19, E J Duiverman1,2, A E J Dubois1,2. 1. Department of Pediatric Pulmonology and Pediatric Allergy, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. 2. University of Groningen, University Medical Centre Groningen, GRIAC Research Institute, Groningen, the Netherlands. 3. Department of General Practice, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. 4. Department of Paediatric Allergy, Martini Hospital, Utrecht, the Netherlands. 5. Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands. 6. Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland. 7. Faculty of Economics and Sociology, Lodz University, Lodz, Poland. 8. Department of Allergy, University Hospital Ramón y Cajal, IRICYS, Madrid, Spain. 9. Department of Allergy, Hospital Clinico San Carlos, IdISSC, Madrid, Spain. 10. Department of Preventive Medicine, Research Unit, Hospital Clínico San Carlos, IdISSC, Madrid, Spain. 11. Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy. 12. Department of Allergy, Landspitali, University Hospital, Reykjavík, Iceland. 13. Department of Paediatrics and Child Health, Clinical Investigation Unit, Cork University Hospital, University College, Cork, Ireland. 14. Division of Allergy, Department of Chest Diseases, University Hospitals, University of Strasbourg, Strasbourg, France. 15. Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece. 16. Center for Pediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK. 17. Food Safety and Consumer Behaviour, Marketing and Consumer Behaviour Group, Wageningen, the Netherlands. 18. Food and Society Group, School of Agriculture, Food and Rural Development, Newcastle University, Newcastle, UK. 19. Department of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London, UK.
Abstract
BACKGROUND: Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. METHODS: A total of 648 European food-allergic patients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. RESULTS: For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL. CONCLUSIONS: In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.
BACKGROUND: Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergicpatients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergicpatients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. METHODS: A total of 648 European food-allergicpatients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. RESULTS: For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL. CONCLUSIONS: In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.
Authors: Gayatri B Patel; Erinn S Kellner; Elisabeth Clayton; Krishan D Chhiba; Omolola Alakija; Paul J Bryce; Joshua B Wechsler; Anne Marie Singh Journal: Ann Allergy Asthma Immunol Date: 2021-03-19 Impact factor: 6.248
Authors: Darío Antolín-Amérigo; Luis Manso; Marco Caminati; Belén de la Hoz Caballer; Inmaculada Cerecedo; Alfonso Muriel; Mercedes Rodríguez-Rodríguez; José Barbarroja-Escudero; María José Sánchez-González; Beatriz Huertas-Barbudo; Melchor Alvarez-Mon Journal: Clin Mol Allergy Date: 2016-02-17