Smyrnova Ganna1. 1. Departamento de Medicina, Universidade de Medicina Nacional M. Gorky, Donetsk, Ucrânia. Electronic address: a.smyrnova@mail.ru.
Abstract
OBJECTIVES: The aim of this study was to evaluate the prevalence of anaemia in rheumatoid arthritis (RA). PATIENTS AND METHODS: 89 patients who fulfilled American College of Rheumatology (ACR) criteria for RA were included in this study. The mean disease duration was 10.9±8.8 years. All patients received methotrexate (10.5±5.5 mg/week) in combination with folic acid. Steroid hormones were prescribed to 92% (19.3±3.8 mg/day) of patients. Erythrocyte sedimentation rate (ESR) and levels of hemoglobin, C-reactive protein (CRP), tumour necrosis factor-alpha (TNFα) and interleukin-1 beta (IL-1β) were evaluated in all patients. The World Health Organization (WHO) criteria for anaemia uses a hemoglobin threshold of <120 g/L for women and <130 g/L for men. RESULTS: Anaemia was observed in 57 (64%) of the patients (1st group), the other patients (2nd group) had normal levels of hemoglobin (135.5±10.7 g/L). Duration and activity of RA were significantly higher (p<0.05) in the 1st group compared with the 2nd. ESR, CRP, TNFα, and IL-1β mean levels were significantly increased (p<0.05) in the 1st group when compared with the 2nd group. Negative correlations between hemoglobin level and ESR, CRP, TNFα, and IL-1β concentrations were observed. CONCLUSION: This study showed for the first time in Ukraine that in 46% of patients with RA, anaemia was diagnosed. A reduction of hemoglobin level was associated with a high activity of disease.
OBJECTIVES: The aim of this study was to evaluate the prevalence of anaemia in rheumatoid arthritis (RA). PATIENTS AND METHODS: 89 patients who fulfilled American College of Rheumatology (ACR) criteria for RA were included in this study. The mean disease duration was 10.9±8.8 years. All patients received methotrexate (10.5±5.5 mg/week) in combination with folic acid. Steroid hormones were prescribed to 92% (19.3±3.8 mg/day) of patients. Erythrocyte sedimentation rate (ESR) and levels of hemoglobin, C-reactive protein (CRP), tumour necrosis factor-alpha (TNFα) and interleukin-1 beta (IL-1β) were evaluated in all patients. The World Health Organization (WHO) criteria for anaemia uses a hemoglobin threshold of <120 g/L for women and <130 g/L for men. RESULTS:Anaemia was observed in 57 (64%) of the patients (1st group), the other patients (2nd group) had normal levels of hemoglobin (135.5±10.7 g/L). Duration and activity of RA were significantly higher (p<0.05) in the 1st group compared with the 2nd. ESR, CRP, TNFα, and IL-1β mean levels were significantly increased (p<0.05) in the 1st group when compared with the 2nd group. Negative correlations between hemoglobin level and ESR, CRP, TNFα, and IL-1β concentrations were observed. CONCLUSION: This study showed for the first time in Ukraine that in 46% of patients with RA, anaemia was diagnosed. A reduction of hemoglobin level was associated with a high activity of disease.
Authors: Julio J Jauregui; Bhaveen H Kapadia; Anant Dixit; Qais Naziri; David J Hip-Flores; Steven F Harwin; Michael A Mont Journal: Clin Rheumatol Date: 2015-08-04 Impact factor: 2.980
Authors: Andrea Rubbert-Roth; Daniel E Furst; Stefano Fiore; Amy Praestgaard; Vivian Bykerk; Clifton O Bingham; Christina Charles-Schoeman; Gerd Burmester Journal: Arthritis Res Ther Date: 2022-08-25 Impact factor: 5.606