BACKGROUND: Increasing evidence has emerged that there is a link between body weight and the risk of developing dementia. However, the relationship between adiposity and brain structure has not yet been fully elucidated. We aimed to evaluate the association of body fat composition with cortical thickness in cognitively normal subjects. METHODS: In total, 1777 (887 men and 890 women) cognitively normal subjects, aged 45 years or older, were recruited from the Health Promotion Center in South Korea. Medical records including 3-dimensional magnetic resonance imaging, body fat percentage, waist-hip ratio (WHR), and other factors were reviewed. RESULTS: In men, the percentage of fat was positively associated with cortical thickness and the highest WHR group showed significantly decreased cortical thickness compared with the reference group. WHR showed an inverted U-shaped association with total cortical thickness and frontal lobe thickness in men. Among women, there was no significant association. CONCLUSIONS: Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness.
BACKGROUND: Increasing evidence has emerged that there is a link between body weight and the risk of developing dementia. However, the relationship between adiposity and brain structure has not yet been fully elucidated. We aimed to evaluate the association of body fat composition with cortical thickness in cognitively normal subjects. METHODS: In total, 1777 (887 men and 890 women) cognitively normal subjects, aged 45 years or older, were recruited from the Health Promotion Center in South Korea. Medical records including 3-dimensional magnetic resonance imaging, body fat percentage, waist-hip ratio (WHR), and other factors were reviewed. RESULTS: In men, the percentage of fat was positively associated with cortical thickness and the highest WHR group showed significantly decreased cortical thickness compared with the reference group. WHR showed an inverted U-shaped association with total cortical thickness and frontal lobe thickness in men. Among women, there was no significant association. CONCLUSIONS: Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness.
Authors: Michelle R Caunca; Hannah Gardener; Marialaura Simonetto; Ying Kuen Cheung; Noam Alperin; Mitsuhiro Yoshita; Charles DeCarli; Mitchell S V Elkind; Ralph L Sacco; Clinton B Wright; Tatjana Rundek Journal: Neurology Date: 2019-07-24 Impact factor: 11.800
Authors: Hye-Mi Noh; Junhee Han; Yeo Jin Kim; Jin-Hyung Jung; Yong Kyun Roh; Hong Ji Song Journal: Medicine (Baltimore) Date: 2019-03 Impact factor: 1.889
Authors: Sung Hoon Kang; Jong Hyuk Kim; Yoosoo Chang; Bo Kyoung Cheon; Yeong Sim Choe; Hyemin Jang; Hee Jin Kim; Seong-Beom Koh; Duk L Na; Kyunga Kim; Sang Won Seo Journal: Front Aging Neurosci Date: 2022-07-22 Impact factor: 5.702