| Literature DB >> 25626421 |
Tony K H Chung1, Paul Van Hummelen2, Paul K S Chan3, Tak Hong Cheung1, So Fan Yim1, Mei Y Yu4, Matthew D Ducar2, Aaron R Thorner2, Laura E MacConaill2, Graeme Doran5, Chandra Sekhar Pedamallu6,7, Akinyemi I Ojesina6,7, Raymond R Y Wong8, Vivian W Wang9, Samuel S Freeman6, Tat San Lau1, Joseph Kwong1, Loucia K Y Chan1, Menachem Fromer10, Taymaa May11, Michael J Worley12, Katharine M Esselen12, Kevin M Elias12, Michael Lawrence13, Gad Getz13, David I Smith9, Christopher P Crum14, Matthew Meyerson2,6,7, Ross S Berkowitz12, Yick Fu Wong1,12.
Abstract
Although the rates of cervical squamous cell carcinoma have been declining, the rates of cervical adenocarcinoma are increasing in some countries. Outcomes for advanced cervical adenocarcinoma remain poor. Precision mapping of genetic alterations in cervical adenocarcinoma may enable better selection of therapies and deliver improved outcomes when combined with new sequencing diagnostics. We present whole-exome sequencing results from 15 cervical adenocarcinomas and paired normal samples from Hong Kong Chinese women. These data revealed a heterogeneous mutation spectrum and identified several frequently altered genes including FAT1, ARID1A, ERBB2 and PIK3CA. Exome sequencing identified human papillomavirus (HPV) sequences in 13 tumors in which the HPV genome might have integrated into and hence disrupted the functions of certain exons, raising the possibility that HPV integration can alter pathways other than p53 and pRb. Together, these provisionary data suggest the potential for individualized therapies for cervical adenocarcinoma based on genomic information.Entities:
Keywords: HPV; cervical adenocarcinoma; genomic alternations
Mesh：
Year: 2015 PMID： 25626421 DOI： 10.1002/ijc.29456
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396