Literature DB >> 25625596

General and chemoselective bisphosphonylation of secondary and tertiary amides.

Ai-E Wang1, Zong Chang, Wei-Ting Sun, Pei-Qiang Huang.   

Abstract

With Tf2O as the activation reagent, a mild and general method has been developed for the bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient and chemoselective, and it tolerates a number of sensitive functional groups such as cyano, ester, and aldehyde groups.

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Year:  2015        PMID： 25625596     DOI： 10.1021/acs.orglett.5b00004

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  One-Pot and Catalyst-Free Transformation of N-Protected 1-Amino-1-Ethoxyalkylphosphonates into Bisphosphonic Analogs of Protein and Non-Protein α-Amino Acids.

Authors:  Anna Kuźnik; Dominika Kozicka; Wioleta Hawranek; Karolina Socha; Karol Erfurt
Journal:  Molecules       Date:  2022-06-02       Impact factor: 4.927

2.  Microwave-assisted synthesis of (aminomethylene)bisphosphine oxides and (aminomethylene)bisphosphonates by a three-component condensation.

Authors:  Erika Bálint; Ádám Tajti; Anna Dzielak; Gerhard Hägele; György Keglevich
Journal:  Beilstein J Org Chem       Date:  2016-07-19       Impact factor: 2.883

3.  Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions.

Authors:  Veronica Tona; Boris Maryasin; Aurélien de la Torre; Josefine Sprachmann; Leticia González; Nuno Maulide
Journal:  Org Lett       Date:  2017-05-09       Impact factor: 6.005

4.  Reactions of Piperazin-2-one, Morpholin-3-one, and Thiomorpholin-3-one with Triethyl Phosphite Prompted by Phosphoryl Chloride: Scope and Limitations.

Authors:  Rubén Oswaldo Argüello-Velasco; Błażej Dziuk; Bartosz Zarychta; Mario Ordóñez; Paweł Kafarski
Journal:  ACS Omega       Date:  2019-05-22

5.  Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes.

Authors:  Qing Yuan; Hua-Wei Liu; Zhong-Jian Cai; Shun-Jun Ji
Journal:  ACS Omega       Date:  2021-03-17
  5 in total

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