Literature DB >> 25624865

System for monitoring UV radiation level in phototherapy cabins in Poland.

Joanna Narbutt1, Mariola Pawlaczyk2, Anna Sysa-Jędrzejowska3, Janusz W Krzyścin4, Piotr Sobolewski4, Bonawentura Rajewska-Więch4, Aleksandra Lesiak1.   

Abstract

INTRODUCTION: Ultraviolet phototherapy (UVP) is widely used in dermatological practice for the treatment of various skin diseases. Numerous studies support its beneficial curing effectiveness; however, overexposure to ultraviolet radiation can cause adverse health effects, such as sunburn reaction, erythema response, cataract, skin aging, etc. For these reasons, it is of special importance to monitor performance of UVP cabins using a calibration system to evaluate the UV doses incident upon the patient.
MATERIAL AND METHODS: A mechanized cabin control system (CCS) is proposed. It consists of radiometers with a wide and narrow field of view to estimate the body irradiation and to identify malfunctioning cabin tubes. Quality control and quality assurance procedures are developed to keep high accuracy of the calibration procedure. The CCS has been used in the examination of two different types of UVP cabins routinely working in Poland.
RESULTS: It allows precise calculation of UV doses and spatial variability of UV radiance inside the cabin, thus providing uncertainties of the doses assigned by medical staff. The CCS could potentially serve as a primary standard for monitoring various UVP cabins working in Poland.
CONCLUSIONS: The methodology developed to quantify UV doses in UVP cabins may be easily extended to any UV radiation source.

Entities:  

Keywords:  UV radiation; dose calibration; medical cabinet; phototherapy

Year:  2014        PMID: 25624865      PMCID: PMC4296080          DOI: 10.5114/aoms.2014.47834

Source DB:  PubMed          Journal:  Arch Med Sci        ISSN: 1734-1922            Impact factor:   3.318


Introduction

Ultraviolet (UV) therapy has been used for decades in the treatment of skin diseases, mainly psoriasis, vitiligo, cutaneous T-cell lymphoma, and eczema [1, 2]. The effectiveness of artificial UV light in different skin therapies is well documented [3, 4]. UV therapy cabins are used in dermatology worldwide. Various fluorescent emitting tubes, e.g. narrowband UVB (311 nm) – TL01, broadband UVB – TL12, and broadband UVA – TL09 (for psoralen UVA therapy), could be arranged in a round assembly to provide strong UV radiation exceeding the maximum of the solar irradiance that reaches the Earth's surface. Determination of the irradiance at the patient's skin surface requires the use of calibrated radiometers [5]. The radiometers contain filters to select the waveband corresponding to that of the cabin UV tubes and have specific spectral sensitivity varying significantly between sensors made even by the same manufacturing company. Thus, a comparison of the radiometer reading with irradiance measurements from a calibrated spectroradiometer and measurements of the radiometer spectral sensitivity are necessary to convert output of the radiometer (in volts) to the irradiance scale (mW · cm−2) [5]. Martin et al. [6] reported variations of 50% in the cabinet irradiance measurements made by different radiometers having the same calibration procedure with a high resolution spectrophotometer. The differences were caused by specific angular properties of the radiometer detector, and radiometers with good angular responses should have been recommended for the cabinet measurements [7]. Curie et al. [8] proposed an automated dosimetry system for testing whole-body ultraviolet phototherapy in dermatological cabins and demonstrated variations in the irradiance measured inside the cabin. The system has not been put into operational use probably because of its calibration procedure that requires regular comparisons of the system UV detectors with a high resolution spectroradiometer during simultaneous measurements in a dermatological cabin. Accurate estimation of the UV dose received by a patient during phototherapy remains a problem. One possible method is to measure the cabin UV intensity at different body points performed by a UV-protected operator using a personal hand-held dosimeter calibrated for the spectrum of the tubes used [9]. The measured doses are then averaged and this mean value represents the cabin irradiance, which is then multiplied by a patient's exposure duration to estimate the UV radiation dose received during the phototherapy treatment. This method is characterized by a large uncertainty and the calibrations differ markedly between specialist centers. For example, TL-01 calibration in the UK varies by at least a factor of 2.7 [10]. There were clinics, however, which either did not have reliable hand-held dosimeters or did not trust their output, and in order to obtain an estimation of patient dosage they performed measurements using a radiometer built in a cabin and computer software evaluating the dosage from this radiometer data or delivered the patient a dosage based on exposure time only [4]. Such methodology was also routinely implemented in two examined cabins in Poland, one located in Poznan (later in the text referred to as Poznan phototherapy cabin, PPC) and another in Lodz (LPC). The dose received by a patient was based on output of the built-in dosimeter in PPC, while in LPC it was based on the exposure time. It is of special importance to control and quantify the patient's radiation dose to ensure both the safety and the effectiveness of the cabin therapy. In this paper we propose a cabin calibration system (CCS) to improve the current dosimetry methods used in Poland and to aid the patient treatments in order to maximize therapeutic efficiency. The proposed system is based on the Curie et al. [8] calibration concept of using two UV sensitive instruments rotating inside the cabinet to determine the doses received by a patient during the medical treatment and to identify malfunctioning tubes. In our solution, different instruments of the system are used and we propose a novel calibration procedure of radiometers measuring the UV irradiance by fluorescent tubes. Details of the UV distribution in the cabin and the tube aging process are also discussed with a view to extending our knowledge of the long-term performance of the cabin.

Material and methods

The phototherapy cabins

Two types of medical cabins were examined: MEDISUN 2800 PC-AB in Lodz, and MEDISUN-2800-44-PC-AB in Poznan. The whole body phototherapy was performed in those cabins using narrow band UVB (TL-01) and broadband UVA (TL-09 UV-A) fluorescent tubes (Philips Lighting B.V., Roosendall, the Netherlands). The irradiance spectra of the tubes, measured inside the cabin by a USB2000+ spectrophotometer (Ocean Optics Inc., Dunedin, Florida, USA), are shown in Figure 1. There are 12 TL-01 and 16 TL-09, and 16 TL-01 and 32 TL-09 tubes mounted in a round assembly in LPC and PPC, respectively, as presented in Figure 2.
Figure 1

Spectra of the radiation by the narrow band UVB TL-01 and broadband UVA TL-09 tubes used in the phototherapy cabin in Lodz and Poznan (A). The normalized sensitivity spectrum of YES UVA-1 meter and the tube spectra weighted by the normalized sensitivity of YES UVA-1 meter (B)

Figure 2

Tube configuration in MEDISUN-2800 PC-AB (Lodz, top) and MEDISUN-2800-44-PC AB (Poznan, bottom) cabin and position of the calibration unit in the centre. Full and open circles mark narrow band UVB TL-01 tubes and broad band UVA TL-09 tubes, respectively. The arrows show the anticlockwise rotation of the calibration unit. The rotation angles are shown round in the circle

Spectra of the radiation by the narrow band UVB TL-01 and broadband UVA TL-09 tubes used in the phototherapy cabin in Lodz and Poznan (A). The normalized sensitivity spectrum of YES UVA-1 meter and the tube spectra weighted by the normalized sensitivity of YES UVA-1 meter (B) Tube configuration in MEDISUN-2800 PC-AB (Lodz, top) and MEDISUN-2800-44-PC AB (Poznan, bottom) cabin and position of the calibration unit in the centre. Full and open circles mark narrow band UVB TL-01 tubes and broad band UVA TL-09 tubes, respectively. The arrows show the anticlockwise rotation of the calibration unit. The rotation angles are shown round in the circle In Lodz the UV dose (J · cm−2) received by a patient during the phototherapy treatment is estimated using a joulemeter. The duration of the cabin irradiation of a patient compliant with the UV dose prescribed by a medical doctor is set by nursing staff. Thus, a constant intensity of the tube radiation is assumed and the received UV dose is proportional to the duration of the cabin treatment. The duration of the irradiation in the Poznan cabin is determined according to the prescribed individual patient dose and the measured irradiation by the built-in cabin radiometer. In such a way a loss of the tube power due to the aging processes, which may happen after prolonged use of the tubes, may be compensated by a longer duration of the phototherapy.

Cabin control system

We examined the performance of the tubes using the CCS, which consists of a commercial meter, YES UVA-1 ultraviolet pyranometers (Yankee Environmental System Inc., Turner Fall, MA, USA), with a wide field of view (almost hemispherical) to estimate the irradiation (in mW · cm−2) on the surface, and two prototype meters, developed by the Tele & Radio Research Institute, Warsaw, containing Schottky diodes with a narrow viewing angle (~40°) to identify small-scale spatial variability in UV radiation field in the cabin. One of the narrow viewing angle (NVA) meters contains a GaN/AIGaN diode which is sensitive to UVB radiation from TL-01 tubes. The other one, with a GaN/AIGaN p-i-n diode that measures mostly UVA radiation, was designed to monitor TL-09 tubes. Below we use the acronyms NVA-UVB and NVA-UVA, respectively, to denote the two meters. The UV monitoring instruments were mounted on a remote control rotating device, which allows one to quantify UV irradiance coming from different sectors of the cabin. The automated system provides a reproducible technique for cabin monitoring and reveals more detailed information on the UV irradiance distribution within the cabin. The details of the CCS calibration procedure are included in the supplementary information section for this article.

UV measurements in the cabin

The measurements of the UV irradiation in the center of the cabin were carried out by the CCS mounted on a vertical bar (Figure 3) that could rotate due to the motorized system. The CCS measured the UV changes inside the cabin during 360° rotation at 3 selected vertical levels corresponding to the height of a human face, chest, and stomach. The measurements of the UV intensity by the CCS consisted of the following stages:
Figure 3

The calibration meters mounted on a vertical plate that is attached to a rotating vertical beam. Its rotation is due to the motorized system (bottom)

fixed position (in front of one of the cabin walls) for about 60 s, rotation in the anticlockwise direction to make a full (360°) circle for about 240 s, fixed position as in stage 1; the resting time lasts about 60 s, rotation in the clockwise direction and after about 240 s arrival at the initial position (stage 1), fixed position for about 60 s as in stage 1. The calibration meters mounted on a vertical plate that is attached to a rotating vertical beam. Its rotation is due to the motorized system (bottom) The procedure, referred to below as Mode A of the cabin examination, was used to estimate the UV variability inside the cabin. The measuring sensor was placed at the distance of 15 cm from the rotating axe (Figure 3), as the irradiated parts of the patient's body are usually outside the geometric centre of the cabin. The effects of the patient's presence in the cabin on the UV level were examined using a manikin. The manikin absorbs part of the radiation and reduces the multiple reflectance between the cabin walls. There are two options: one with an undressed and another with a dressed manikin (Figure 4). During the experiment, the CCS was fixed as in stage 1, and the manikin stood just behind the measuring unit. The fixed position of the CCS in front of the cabin wall is referred to as Mode B of the cabin examination.
Figure 4

The calibration session in the phototherapy cabin in Lodz with naked (A) and dressed manikin (B)

The calibration session in the phototherapy cabin in Lodz with naked (A) and dressed manikin (B) The CCS is designed to compare the UV doses with nominal doses previously assigned by nursing staff. The selected nominal doses were 1.4 J · cm−2 and 5 J · cm−2 for TL-01 and TL-09 tubes in LPC, respectively. In PPC only TL-01 tubes were examined, and a 2.0 J · cm−2 dose was selected for the calibrations because the broad band UVA phototherapy by TL-09 tubes is rarely prescribed to a patient. The selected nominal doses correspond to those used in medical practice [11, 12].

Results

Cabinet measurements

Examples of the UV irradiance emitted by TL-01 tubes in the experiments in Lodz and Poznan performed in Mode A are shown in Figures 5. Figure 5A shows the irradiance time series by YES UVA-1 measured at each stage of Mode A. In Lodz, in stage 1 (1st min of the cabinet operation), the UV irradiance increased only slightly during warming of the tubes. In Poznan, the measurements in PPC started with a jump after which the cabin software adjusts the UV intensity to lower values, and a few seconds later a slight upward tendency in the tube irradiation appears. The irradiance fluctuated in stages 2 and 4 because the radiometer measured the UV radiation coming from different sectors of the cabin walls. The UV level in the Poznan cabin was higher because PPC contains more tubes, 16, in comparison with LPC, 12. The range of UV fluctuations, which was measured as the difference between the maximum and the minimum irradiance recorded during the CCS rotations, was ~1 mW · cm−2 in LPC, being twice as large as that in PPC. In stages 3 and 5 the irradiance level was almost constant. The calibration procedure (Mode A) of the cabin status lasted about 11 min. The irradiance level at the end of the procedure was only slightly lower than that at the start.
Figure 5

The irradiance time series measured during the calibration of narrow band tubes in phototherapy cabins in Lodz and Poznan: Mode A of the calibration schedule by YES UVA-1 radiometer (A), step 2 and 4 of Mode A by the narrow viewing angle instrument NVA UVB (B)

The irradiance time series measured during the calibration of narrow band tubes in phototherapy cabins in Lodz and Poznan: Mode A of the calibration schedule by YES UVA-1 radiometer (A), step 2 and 4 of Mode A by the narrow viewing angle instrument NVA UVB (B) Figure 5B shows the irradiance variability in stages 2 and 4, i.e., only during the CCS rotation, measured by the NVA-UVB meter in LPC and PPC. In this case the UV radiance incident upon the instrument sensor comes from a small area of the cabin, as the viewing angle of the instrument is about 40°. The variability of UV radiation was much higher compared to that obtained by YES UVA-1. In certain positions (cabinet corners), the NVA-UVB meter registered only UV radiation reflected from the cabinet walls outside the influence of direct lamp radiation. The irradiance field in the cabin was smoother in PPC because more tubes were used. During the clockwise rotation of the CCS in LPC (step 4 of Mode A) the irradiance was only slightly lower than that during anticlockwise rotation (step 2 of Mode A). This was probably due to lower efficiency of the tube at higher temperature and/or due to the temperature sensitivity of semiconductors used in NVA meters. The computer software controls the tube efficiency in PPC taking into account irradiation measured by the built-in UV meter. Thus, sometimes the irradiance during the clockwise turning is slightly higher than that during the anticlockwise turning. The examination of the cabin with NVA meters allowed the performance of individual tubes to be monitored and indicated a loss of their power due to aging of the tubes. Thus, it seems also possible to identify the malfunctioning tubes. YES UVA-1 is more appropriate to determine the irradiation of a patient body, as it is sensitive to radiance coming from a wide hemispherical area of the cabin that corresponds to the field-of-view of the patient's skin during the phototherapy.

Measured versus nominal doses in the empty cabin

Table I shows the ratio between nominal doses that a patient should receive during phototherapy in LPC and the actual dose measured at different levels corresponding to the height of the stomach, chest, and face of a patient 175 cm tall. The results are for two data sets extracted from Mode A measurements:
Table I

Ratio between nominal and measured doses in Lodz cabin (MEDISON 2800-PC_AB) obtained during 3 comparison campaigns in 2010 for the narrow band UVB TL-01 tubes (NUVB) and broadband UVA TL-09 tubes (BUVA). The total work time since the last replacement of all tubes is shown in the last row. ROT_FIX denotes measurements comprising anticlockwise and clockwise rotation of the calibration unit in the cabin and fixed position of about 1 min before anticlockwise and after clockwise rotation. ROT denotes measurements only during anticlockwise and clockwise rotation

April, 10June, 19November, 23
NUVBBUVANUVBBUVANUVBBUVA
Stomach:
 ROT_FIX1.021.140.961.130.961.05
 ROT0.971.120.941.130.891.05
Chest:
 ROT_FIX0.951.130.911.130.901.07
 ROT0.891.150.861.140.821.07
Face:
 ROT_FIX0.851.030.821.060.810.97
 ROT0.791.040.771.060.740.97
Work time [h] 94511411431411485175
full series of measurements comprising all stages (1–5) of Mode A, part of a full series including only measurements in periods with CCS rotations (stage 2 and 4 of Mode A). Ratio between nominal and measured doses in Lodz cabin (MEDISON 2800-PC_AB) obtained during 3 comparison campaigns in 2010 for the narrow band UVB TL-01 tubes (NUVB) and broadband UVA TL-09 tubes (BUVA). The total work time since the last replacement of all tubes is shown in the last row. ROT_FIX denotes measurements comprising anticlockwise and clockwise rotation of the calibration unit in the cabin and fixed position of about 1 min before anticlockwise and after clockwise rotation. ROT denotes measurements only during anticlockwise and clockwise rotation Doses produced by the narrow band UVB (TL-01) and the broad band UVA (TL-09) tubes were compared in three sessions in 2010 (April 10, June 19, and November 23). The nominal and observed doses were in good agreement. The ratio (nominal dose divided by the CCS measured dose) was within the range 0.82–1.15 at the level of the stomach and chest (Tables I and II), i.e., for a significant part of the patient's body. The nominal doses assigned in the broad band UVA therapy were only slightly larger than those measured by the CCS, whereas the nominal doses were slightly smaller than the measured ones for the narrow band UVB tubes.
Table II

Ratio between nominal and measured doses in Poznan cabin (MEDISON 2800-44-PC_AB) during the comparison campaign in April, 2010 for the narrow band UVB TL-01 tube. ROT_FIX and ROT abbreviations are the same as in Table I. FIX denotes the fixed position of the calibration unit in front of the cabin wall

ROT_FIXROTFIX
Stomach 0.880.830.94
Chest 0.870.820.90
Face 0.760.750.82
The ratio between the nominal and measured doses in LPC usually decreased when comparing the ratio for doses measured only during the rotating phase of measurements (stage 2 and stage 4) with the ratio obtained for the whole Mode A (Table I). More irradiation was received by the CCS in a fixed position. During the rotations, lower irradiation was recorded from the corner zones of the cabin (45°, 135°, 225°, and 315°, see Figure 2). The difference between the ratios for the rotating phase and the whole Mode A is smaller for the broad band UVA lamp, because TL-09 tubes were spread more evenly in the cabin. The measured UV doses decreased with the height, especially between the chest and face level, and the change was about 10%. The same pattern of the UV variability inside the cabin was found for PPC in the tests carried out in April 2010, but the ratio between the nominal and measured doses was about 10% lower (Table II) than that measured during the examination of LPC. The measured doses were closer to the nominal ones, especially at the stomach level, if the CCS was fixed in front of 45°–0°–315° cabin wall as it is in Figure 2. Ratio between nominal and measured doses in Poznan cabin (MEDISON 2800-44-PC_AB) during the comparison campaign in April, 2010 for the narrow band UVB TL-01 tube. ROT_FIX and ROT abbreviations are the same as in Table I. FIX denotes the fixed position of the calibration unit in front of the cabin wall After approx. 500 h of the narrow band UVB phototherapy and approx. 65 h of the broad band UVA phototherapy in LPC, there were small changes in the tube efficiency (within 10% accuracy of the irradiance measurements). Figures 6 and 7 show the time series of the measured irradiance in April, June, and November calibration sessions, for the narrow band UVB and broad band UVA tubes, respectively. Figure 6A illustrates a slight deterioration (~10%) of TL-01 tube efficiency in the 5-month period. The results shown in Figures 6B and Figure 7 were obtained during the clockwise (step 4 of Mode A) rotation of the CCS at the height corresponding to the chest level. Figures 6B shows the irradiance changes during the clockwise rotation between 360° and 180° (Figure 2 for the selected cabin sector) by the NVA-UVB meter. The irradiances by TL-09 tubes (Figure 7) decreased only slightly between April 10 and June 19 calibrations, but there was a decrease of about 10% between June 19 and November 23. The decrease in the measured irradiation may be related to tube aging that may occur abruptly after a period of stable work of the cabin tubes.
Figure 6

The irradiance time series measured in the Lodz cabin, with the narrow band UVB TL-01 working tubes, during clockwise rotations of the CCS: YES UVA-1 data (A), NVA-UVB data zoomed on a part of the clockwise rotation (B)

Figure 7

The irradiance time series measured during the clockwise rotations of YES UVA-1 in the calibration sessions of the Lodz cabin with the broad band UVA TL-09 working tubes

The irradiance time series measured in the Lodz cabin, with the narrow band UVB TL-01 working tubes, during clockwise rotations of the CCS: YES UVA-1 data (A), NVA-UVB data zoomed on a part of the clockwise rotation (B) The irradiance time series measured during the clockwise rotations of YES UVA-1 in the calibration sessions of the Lodz cabin with the broad band UVA TL-09 working tubes Surprisingly, during the November measurements of the cabin irradiation by the narrow band UVB tubes, we found regions (Figure 6A, around 0°–20°, and Figure 6B, around 315°–360°) with larger irradiance than was measured in previous intercomparisons. It was explained to us by the nursing staff that two malfunctioning tubes, which were mounted at 45°–0°–315° wall, had been replaced with new ones. Signs of tube malfunctioning, i.e., light flickering, had been noticed earlier on (before the November comparison) by a patient.

Attenuation of UV doses by a manikin

Assessment of the cabin performance requires the irradiance measurements with and without a person in the cabinet to establish a correction factor accounting for the presence of the body, which itself absorbs UV radiation [5]. The body correction factor varies between 0.80 and 0.96, and it depends on the cabinet design and patient posture [13, 14]. Table III shows the comparison between the nominal and measured dose results with a fixed position of the CCS (Mode B) for an empty cabin, an undressed manikin, and a dressed manikin inside the cabin at two heights corresponding to the stomach level (Figure 4 – top) and the chest level (Figure 4 – bottom). The attenuation of the UV dose with the undressed and dressed manikin was more apparent for the UV irradiation by the broad band tubes than that for the narrow band ones, i.e.,
Table III

Ratio between nominal and measured doses in Lodz cabin from the comparison session with (or without) a manikin fixed in front of the cabin wall (Figure 4). Three options were examined: without manikin (NO_M), naked manikin (MN), and dressed manikin (MD). The results are for narrow band UVB TL-01 tubes (NUVB) and broadband UVA TL-09 tubes (BUVA) and two levels of the measuring unit: stomach and chest

NUVBBUVA
StomachChestStomachChest
NO_M 1.231.181.191.21
MN 1.161.141.071.09
MD 1.121.041.021.02
naked manikin: 12% (both the stomach and the chest level) for the broad band UVA compared to 7% (stomach), and 4% (chest) for the narrow band UVB, dressed manikin: 17% (stomach) and 19% (chest) for the broad band UVA compared to 11% (stomach) and 14% (chest) for the narrow band UVB. Ratio between nominal and measured doses in Lodz cabin from the comparison session with (or without) a manikin fixed in front of the cabin wall (Figure 4). Three options were examined: without manikin (NO_M), naked manikin (MN), and dressed manikin (MD). The results are for narrow band UVB TL-01 tubes (NUVB) and broadband UVA TL-09 tubes (BUVA) and two levels of the measuring unit: stomach and chest The attenuation of the cabin irradiation by the dressed manikin (and the undressed manikin for the broadband UV tubes) was statistically significant, since the uncertainty of the UV irradiance measurements by the CCS was around 10%. The manikin (such as normally used in clothes shops) simulates a rather thin patient, whereas the dressed manikin imitates the presence of a stockier patient in the cabin. The attenuation range found by the CCS in LPC corresponds to the correction factor obtained in earlier studies [14]. Table III shows that the nominal doses set by the nursing staff were about 20% higher than the ones measured by the CCS for Mode B of LPC testing. The agreement between the doses is better when the cabin is occupied by the manikin. The agreement will be even better for a normal patient. Thus, at the moment we do not recommend using the body correction factor for nominal doses set by nursing staff for the UV exposures in the Lodz cabinet.

Discussion

The automated system for testing phototherapy cabinets proposed by Curie et al. [8] was used in parallel with manual measurements by a Macam 203 meter to evaluate its performance. Both the automated system and the hand-held UV radiometer were calibrated in the cabin during simultaneous measurements with a high-resolution spectrophotometer. Thus, almost a perfect agreement between doses by the automated system and the radiometer was not surprising. Polish cabinets are not equipped with hand-held personal radiometers, so testing of the cabinet performance could be done comparing the measured UV doses by the proposed system with nominal doses assigned by nursing staff according to medical doctor prescriptions. It is worth mentioning that some authors questioned the effectiveness of the hand-held radiometers for the cabin calibration [6, 10]. The CCS is based on the Curie et al. [8] calibration concept of using wide-angle and narrow-angle view sensors rotating inside the cabinet, but different instruments are implemented. The basic instrument of our system, a commercial broadband radiometer routinely used at meteorological stations for UVA monitoring, YES UVA-1, with an almost hemispherical field of view and a small cosine error, is a temperature-stabilized meter (at 45°C). Thus it allows precise measurement of UV radiation in an environment with large temperature variability. The temperature in the centre of the cabin may increase from room temperature at the start to about 40°C after ~10 min’ operation. The uncertainty of the cabin UV irradiance measurements by CCS was estimated as ~10%, which is mostly due to the error of estimation of YES UVA-1 instrumental constants (~6%) to convert its output in volts to solar irradiance in mW · m−2 (for more details see supplementary information). The calibration of our system is done by field comparisons with a routinely operated spectrophotometer (the Brewer spectrophotometer at Central Geophysical Observatory of the Institute of Geophysics, Belsk, Poland) used for continuous measurements of solar UV spectra. Our calibration methodology does not require a set of simultaneous measurements, separately for each lamp category (e.g. narrow band UVB, broadband UVB, broadband UVA), by the system and a high resolution spectrophotometer in a cabinet. The proposed method will have universal applications as it allows one to calibrate any radiometer (with a broad sensitivity band in the UV range) for any kind of UV tube radiation, with known spectral characteristics of its radiation output. The CCS monitored the performance of phototherapy cabins in Lodz (MEDISUN 2800 PC-AB) and Poznań (MEDISUN-2800-44-PC-AB). The nominal doses (J · cm−2) to be received by a patient during the whole body phototherapy, as prescribed by medical doctors, were set differently in the two cabins. In Lodz, the duration of exposure in the cabin was assigned taking into account the value of the prescribed phototherapy dose under the assumption of constant power of the tubes. In Poznan, the appropriate irradiance level and the duration of the phototherapy were adjusted by computer software combined with the built-in meter. Thus, the UV intensity in the cabinet varied throughout phototherapy and the tube aging effect could be compensated by a higher tube voltage. It was found that the UV doses assigned by the nursing staff agreed within ±20% with the doses measured by the CCS. The UV irradiance at the stomach and chest level was slightly (~10%) higher than that measured at the face level. Some parts of the human body therefore could receive significantly different irradiation even at the same level because of the angular changes of UV irradiance inside the cabin. This effect was stronger in Lodz, as the maximum irradiance (in front of the cabin wall) was about 1.0 mW · cm−2 greater than the minimum irradiance (from the corners of the cabin), whereas the difference between the extremes in Poznan was two times lower due to the more evenly distributed UV field owing to more tubes per cabin wall. Thus, for some patients, slow turning around in the cabin during the phototherapy could be a good practice. The examined cabins performed quite well and no corrections of the dosage incident upon a patient were necessary within 5 months of the cabin operation. The narrow viewing instruments of the CCS are designed to identify changes in the tube efficiency. Originally, its aim was detection of a malfunctioning tube, but during the last calibration in the Lodz cabin (November, 2010) we measured an increase in the cabin irradiation in some sectors after earlier replacement of the malfunctioning tubes with new ones. A patient usually informs the nursing staff of damaged tubes when he sees a flickering light, which is an apparent sign of deteriorating operation of a tube. A slight degradation of tubes’ efficiency in the Lodz cabin was detected with hemispherical and narrow viewing instruments. Surprisingly, the cabin aging is more apparent for the broad-band tubes used ~10 times less frequently than the narrow band (311 nm) tubes. Warming and subsequent cooling of non-operating broad-band lamps by surrounding narrow band tubes may be a reason for the declining tendency. Declining tube efficiency is not a problem in Poznan. Should it occur anyway, the loss in efficiency will be compensated thanks to the computer software that will increase the tube voltage and/or extend the duration of phototherapy. In conclusion, the measurements of UV radiation inside the cabins by the proposed calibration system provide evidence that real UV doses received by patients during UV phototherapy in Poznan and Lodz agree well (within the range of ±20%) with the nominal doses assigned by nursing staff. It does not mean that this will be the case for the same type or other type of cabins using even more sophisticated monitoring of UV irradiance by a built-in dosimeter. Cabinet performance testing always requires independent UV measurements by a well-calibrated device [3]. However, our experiences with the CCS suggest that it will be enough if a calibration of the cabin is performed after ~500 h of cabin operation. It cannot be assumed that the cabin performance will be consistent over many years of use. UV therapy quality is only guaranteed if the cabinet performance testing is done with a reliable ultraviolet radiometry instrument. The methodology developed to quantify UV doses in the UVP cabin may be easily extended to measurements of irradiance in the UV-B and UV-A range by any artificial (non-solar) UV radiation source, e.g. UV tubes in solaria. A precondition of starting such measurements is availability of the irradiance spectra of the UV source.
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Journal:  Phys Med Biol       Date:  2001-02       Impact factor: 3.609

2.  The importance of radiometer angular response for ultraviolet phototherapy dosimetry.

Authors:  C J Martin; G D Currie; S D Pye
Journal:  Phys Med Biol       Date:  1999-04       Impact factor: 3.609

3.  Scottish UV dosimetry guidelines, "ScUViDo".

Authors:  H Moseley
Journal:  Photodermatol Photoimmunol Photomed       Date:  2001-10       Impact factor: 3.135

4.  Guidelines for dosimetry and calibration in ultraviolet radiation therapy: a report of a British Photodermatology Group workshop.

Authors:  D K Taylor; A V Anstey; A J Coleman; B L Diffey; P M Farr; J Ferguson; S Ibbotson; K Langmack; J J Lloyd; P McCann; C J Martin; H Du P Menagé; H Moseley; G Murphy; S D Pye; L E Rhodes; S Rogers
Journal:  Br J Dermatol       Date:  2002-05       Impact factor: 9.302

5.  A study of the directional response of ultraviolet radiometers: I. Practical evaluation and implications for ultraviolet measurement standards.

Authors:  S D Pye; C J Martin
Journal:  Phys Med Biol       Date:  2000-09       Impact factor: 3.609

6.  Variation in calibration of hand-held ultraviolet (UV) meters for psoralen plus UVA and narrow-band UVB phototherapy.

Authors:  J J Lloyd
Journal:  Br J Dermatol       Date:  2004-06       Impact factor: 9.302

7.  An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report.

Authors:  S H Ibbotson; D Bilsland; N H Cox; R S Dawe; B Diffey; C Edwards; P M Farr; J Ferguson; G Hart; J Hawk; J Lloyd; C Martin; H Moseley; K McKenna; L E Rhodes; D K Taylor
Journal:  Br J Dermatol       Date:  2004-08       Impact factor: 9.302

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Journal:  Phys Med Biol       Date:  1998-01       Impact factor: 3.609

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Journal:  Br J Dermatol       Date:  2003-12       Impact factor: 9.302

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