Agostino Chiaravalloti1, Alessandro Fiorentini2, Veronica Villani3, Carmine Carapella4, Andrea Pace3, Barbara Di Pietro2, Carmen Di Russo2, Barbara Palumbo5, Roberto Floris2, Orazio Schillaci6. 1. Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy. Electronic address: agostino.chiaravalloti@gmail.com. 2. Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy. 3. Neuro-Oncology Unit, "Regina Elena" National Cancer Institute of Rome, Italy. 4. Division of Neurosurgery "Regina Elena" National Cancer Institute of Rome, Italy. 5. Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy. 6. Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.
Abstract
AIM: To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment. MATERIALS AND METHODS: 97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively. RESULTS: (18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade. CONCLUSIONS: The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake.
AIM: To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment. MATERIALS AND METHODS: 97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively. RESULTS: (18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade. CONCLUSIONS: The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake.
Authors: Ryan S Youland; Deanna H Pafundi; Debra H Brinkmann; Val J Lowe; Jonathan M Morris; Bradley J Kemp; Christopher H Hunt; Caterina Giannini; Ian F Parney; Nadia N Laack Journal: J Neurooncol Date: 2018-01-13 Impact factor: 4.130
Authors: Mariam Aboian; Ramon Barajas; Julia Shatalov; Vahid Ravanfar; Emma Bahroos; Elizabeth Tong; Jennie W Taylor; N Oberheim Bush; Patricia Sneed; Youngho Seo; Soonmee Cha; Miguel Hernandez-Pampaloni Journal: Neurooncol Pract Date: 2020-10-14
Authors: Francesca Pasi; Marco G Persico; Manuela Marenco; Martina Vigorito; Angelica Facoetti; Marina Hodolic; Rosanna Nano; Giorgio Cavenaghi; Lorenzo Lodola; Carlo Aprile Journal: Front Neurosci Date: 2020-11-13 Impact factor: 4.677