Literature DB >> 25624005

Rheumatoid arthritis. The two faces of Rsk2 in hyperplastic disease.

Jane Falconer1, Christopher D Buckley1.   

Abstract

Given the established role of 90 kDa ribosomal S6 kinases (Rsk) in oncogenesis, and the promise of new Rsk-blocking cancer treatments, it is perhaps surprising that Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium. Does this functional duality make Rsk2 a risky target for the treatment of rheumatoid arthritis?

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Year:  2015        PMID： 25624005     DOI： 10.1038/nrrheum.2015.1

Source DB:  PubMed          Journal:  Nat Rev Rheumatol        ISSN： 1759-4790            Impact factor:   20.543


  10 in total

1.  Cadherin-11 in synovial lining formation and pathology in arthritis.

Authors:  David M Lee; Hans P Kiener; Sandeep K Agarwal; Erika H Noss; Gerald F M Watts; Osamu Chisaka; Masatoshi Takeichi; Michael B Brenner
Journal:  Science       Date:  2007-01-25       Impact factor: 47.728

2.  Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.

Authors:  U Müller-Ladner; J Kriegsmann; B N Franklin; S Matsumoto; T Geiler; R E Gay; S Gay
Journal:  Am J Pathol       Date:  1996-11       Impact factor: 4.307

3.  RSK2 protects mice against TNF-induced bone loss.

Authors:  Christina Böhm; Anja Derer; Roland Axmann; Ulrike Hillienhoff; Mario M Zaiss; Julia Luther; Christine Zech; Michael Stock; Carina Scholtysek; Klaus Engelke; Andreas Hess; Jan P Tuckermann; Georg Schett; Jean-Pierre David
Journal:  J Cell Sci       Date:  2012-02-17       Impact factor: 5.285

4.  Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium.

Authors:  G S Firestein; F Echeverri; M Yeo; N J Zvaifler; D R Green
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

5.  Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis.

Authors:  Anja Derer; Christina Böhm; Bettina Grötsch; Joachim R Grün; Andreas Grützkau; Michael Stock; Sybille Böhm; Bettina Sehnert; Udo Gaipl; Georg Schett; Axel J Hueber; Jean-Pierre David
Journal:  Ann Rheum Dis       Date:  2014-11-20       Impact factor: 19.103

6.  Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.

Authors:  Stephanie Lefèvre; Anette Knedla; Christoph Tennie; Andreas Kampmann; Christina Wunrau; Robert Dinser; Adelheid Korb; Eva-Maria Schnäker; Ingo H Tarner; Paul D Robbins; Christopher H Evans; Henning Stürz; Jürgen Steinmeyer; Steffen Gay; Jürgen Schölmerich; Thomas Pap; Ulf Müller-Ladner; Elena Neumann
Journal:  Nat Med       Date:  2009-11-08       Impact factor: 53.440

7.  Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature.

Authors:  John G Facciponte; Stefano Ugel; Francesco De Sanctis; Chunsheng Li; Liping Wang; Gautham Nair; Sandy Sehgal; Arjun Raj; Efthymia Matthaiou; George Coukos; Andrea Facciabene
Journal:  J Clin Invest       Date:  2014-03-18       Impact factor: 14.808

Review 8.  The p90 RSK family members: common functions and isoform specificity.

Authors:  Romain Lara; Michael J Seckl; Olivier E Pardo
Journal:  Cancer Res       Date:  2013-08-22       Impact factor: 12.701

9.  Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Authors:  Yukinori Okada; Di Wu; Gosia Trynka; Towfique Raj; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Shinji Yoshida; Robert R Graham; Arun Manoharan; Ward Ortmann; Tushar Bhangale; Joshua C Denny; Robert J Carroll; Anne E Eyler; Jeffrey D Greenberg; Joel M Kremer; Dimitrios A Pappas; Lei Jiang; Jian Yin; Lingying Ye; Ding-Feng Su; Jian Yang; Gang Xie; Ed Keystone; Harm-Jan Westra; Tõnu Esko; Andres Metspalu; Xuezhong Zhou; Namrata Gupta; Daniel Mirel; Eli A Stahl; Dorothée Diogo; Jing Cui; Katherine Liao; Michael H Guo; Keiko Myouzen; Takahisa Kawaguchi; Marieke J H Coenen; Piet L C M van Riel; Mart A F J van de Laar; Henk-Jan Guchelaar; Tom W J Huizinga; Philippe Dieudé; Xavier Mariette; S Louis Bridges; Alexandra Zhernakova; Rene E M Toes; Paul P Tak; Corinne Miceli-Richard; So-Young Bang; Hye-Soon Lee; Javier Martin; Miguel A Gonzalez-Gay; Luis Rodriguez-Rodriguez; Solbritt Rantapää-Dahlqvist; Lisbeth Arlestig; Hyon K Choi; Yoichiro Kamatani; Pilar Galan; Mark Lathrop; Steve Eyre; John Bowes; Anne Barton; Niek de Vries; Larry W Moreland; Lindsey A Criswell; Elizabeth W Karlson; Atsuo Taniguchi; Ryo Yamada; Michiaki Kubo; Jun S Liu; Sang-Cheol Bae; Jane Worthington; Leonid Padyukov; Lars Klareskog; Peter K Gregersen; Soumya Raychaudhuri; Barbara E Stranger; Philip L De Jager; Lude Franke; Peter M Visscher; Matthew A Brown; Hisashi Yamanaka; Tsuneyo Mimori; Atsushi Takahashi; Huji Xu; Timothy W Behrens; Katherine A Siminovitch; Shigeki Momohara; Fumihiko Matsuda; Kazuhiko Yamamoto; Robert M Plenge
Journal:  Nature       Date:  2013-12-25       Impact factor: 49.962

10.  What can rheumatologists learn from translational cancer therapy?

Authors:  Jonathan P Sherlock; Andrew D Filer; John D Isaacs; Christopher D Buckley
Journal:  Arthritis Res Ther       Date:  2013       Impact factor: 5.156
  10 in total

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