| Literature DB >> 25623488 |
Eun-Kyung Lim1, Joo Oak Keem, Hui-suk Yun, Jinyoung Jung, Bong Hyun Chung.
Abstract
Gold nanoparticle-conjugated fluorescent hydroxyapatite (AuFHAp) was developed as a smart nanoprobe for measuring alkaline phosphatase (ALP) activity. AuFHAp showed NIR fluorescence due to the hydrolysis of its phosphate groups by ALP. In addition, gold nanoparticles help reduce the nonspecific signal by absorbing nonspecific fluorescence. Through in vitro tests, we confirmed that the AuFHAp probe was capable of detecting ALP levels related to osteoblast activity in living cells with high fluorescence intensity.Entities:
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Year: 2015 PMID： 25623488 DOI： 10.1039/c4cc09620g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222