Christian P Kamm1, Heinrich P Mattle2, René M Müri3, Mirjam R Heldner2, Verena Blatter2, Sandrine Bartlome3, Judith Lüthy3, Debora Imboden3, Giovanna Pedrazzini2, Stephan Bohlhalter4, Roger Hilfiker5, Tim Vanbellingen6. 1. Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland christian.kamm@insel.ch. 2. Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland. 3. Division of Cognitive and Restorative Neurology, Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland. 4. Neurology and Neurorehabilitation Center, Luzerner Kantonsspital, Switzerland. 5. HES-SO Valais-Wallis, School of Health Sciences, University of Applied Sciences and Arts Western Switzerland Valais, Sion, Switzerland. 6. Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland/Neurology and Neurorehabilitation Center, Luzerner Kantonsspital, Switzerland.
Abstract
BACKGROUND: Impaired manual dexterity is frequent and disabling in patients with multiple sclerosis (MS), affecting activities of daily living (ADL) and quality of life. OBJECTIVE: We aimed to evaluate the effectiveness of a standardized, home-based training program to improve manual dexterity and dexterity-related ADL in MS patients. METHODS: This was a randomized, rater-blinded controlled trial. Thirty-nine MS patients acknowledging impaired manual dexterity and having a pathological Coin Rotation Task (CRT), Nine Hole Peg Test (9HPT) or both were randomized 1:1 into two standardized training programs, the dexterity training program and the theraband training program. Patients trained five days per week in both programs over a period of 4 weeks. Primary outcome measures performed at baseline and after 4 weeks were the CRT, 9HPT and a dexterous-related ADL questionnaire. Secondary outcome measures were the Chedoke Arm and Hand Activity Inventory (CAHAI-8) and the JAMAR test. RESULTS: The dexterity training program resulted in significant improvements in almost all outcome measures at study end compared with baseline. The theraband training program resulted in mostly non-significant improvements. CONCLUSION: The home-based dexterity training program significantly improved manual dexterity and dexterity-related ADL in moderately disabled MS patients. Trial Registration NCT01507636.
RCT Entities:
BACKGROUND: Impaired manual dexterity is frequent and disabling in patients with multiple sclerosis (MS), affecting activities of daily living (ADL) and quality of life. OBJECTIVE: We aimed to evaluate the effectiveness of a standardized, home-based training program to improve manual dexterity and dexterity-related ADL in MSpatients. METHODS: This was a randomized, rater-blinded controlled trial. Thirty-nine MSpatients acknowledging impaired manual dexterity and having a pathological Coin Rotation Task (CRT), Nine Hole Peg Test (9HPT) or both were randomized 1:1 into two standardized training programs, the dexterity training program and the theraband training program. Patients trained five days per week in both programs over a period of 4 weeks. Primary outcome measures performed at baseline and after 4 weeks were the CRT, 9HPT and a dexterous-related ADL questionnaire. Secondary outcome measures were the Chedoke Arm and Hand Activity Inventory (CAHAI-8) and the JAMAR test. RESULTS: The dexterity training program resulted in significant improvements in almost all outcome measures at study end compared with baseline. The theraband training program resulted in mostly non-significant improvements. CONCLUSION: The home-based dexterity training program significantly improved manual dexterity and dexterity-related ADL in moderately disabled MSpatients. Trial Registration NCT01507636.
Authors: Luis De-Bernardi-Ojuel; Laura Torres-Collado; Manuela García-de-la-Hera Journal: Int J Environ Res Public Health Date: 2021-02-03 Impact factor: 3.390
Authors: Tim J Knobbe; Daan Kremer; Michele F Eisenga; Eva Corpeleijn; Coby Annema; Joke M Spikman; Gerjan Navis; Stefan P Berger; Stephan J L Bakker Journal: Sci Rep Date: 2022-09-28 Impact factor: 4.996
Authors: Judith Jantine Willemijn van Beek; Erwin Everardus Henri van Wegen; Marc Berend Rietberg; Thomas Nyffeler; Stephan Bohlhalter; Christian Philipp Kamm; Tobias Nef; Tim Vanbellingen Journal: JMIR Mhealth Uhealth Date: 2020-06-09 Impact factor: 4.773