Literature DB >> 25623

Regiospecific synthesis of isoapocodeine from 10,11-dimethoxyaporphine by using Cunninghamella elegans.

R V Smith, P J Davis.   

Abstract

A preparative-scale regiospecific conversion of 10,11-dimethoxyaporphine to isoapocodeine was conducted with Cunninghamella elegans ATCC 9245. This biotransformation proceeded quantitatively in suspensions and was pH dependent. The influence of antioxidants on the conversion was studied. Attempts to preserve the activity of isolated C. elegans cells by a number of methods were unsuccessful.

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Year:  1978        PMID： 25623      PMCID： PMC242915          DOI： 10.1128/aem.35.4.738-742.1978

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  Thin-layer chromatography of apomorphine and its analogs.

Authors:  P W Erhardt; R V Smith; T T Sayther; J E Keiser
Journal:  J Chromatogr       Date:  1976-01-07

2.  Microbial models of mammalian metabolism.

Authors:  R V Smith; J P Rosazza
Journal:  J Pharm Sci       Date:  1975-11       Impact factor: 3.534

3.  Pilot plant conversion of steroid using resting cell suspension as biocatalyst.

Authors:  W C McGregor; B Tabenkin; E Jenkins; R Epps
Journal:  Biotechnol Bioeng       Date:  1972-09       Impact factor: 4.530

4.  Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11 methoxyaporphine (isoapocodeine). In vitro enzymatic methylation of apomorphine.

Authors:  J G Cannon; R V Smith; A Modiri; S P Sood; R J Borgman; M A Aleem; J P Long
Journal:  J Med Chem       Date:  1972-03       Impact factor: 7.446

5.  Microbiological synthesis of L-3,4-dihydroxyphenylalanine.

Authors:  C J Sih; P Foss; J Rosazza; M Lemberger
Journal:  J Am Chem Soc       Date:  1969-10-22       Impact factor: 15.419

6.  Apomorphine HCL stabilization.

Authors:  R J Engelhardt; F M Schell; J L Lichtin
Journal:  J Am Pharm Assoc       Date:  1968-04       Impact factor: 2.217

7.  Induction and inhibition of in vivo glucuronidation of apomorphine in mice.

Authors:  P N Kaul; M W Conway
Journal:  J Pharm Sci       Date:  1971-01       Impact factor: 3.534

8.  Treatment of Parkinson's disease with aporphines. Possible role of growth hormone.

Authors:  G C Cotzias; P S Papavasiliou; E S Tolosa; J S Mendez; M Bell-Midura
Journal:  N Engl J Med       Date:  1976-03-11       Impact factor: 91.245

9.  Microbial models of mammalian metabolism. Aromatic hydroxylation.

Authors:  R V Smith; J P Rosazza
Journal:  Arch Biochem Biophys       Date:  1974-04-02       Impact factor: 4.013

10.  Microbial models of mammalian metabolism. O-Dealkylation of 10,11-dimethoxyaporphine.

Authors:  J P Rosazza; A W Stocklinski; M A Gustafson; J Adrian; R V Smith
Journal:  J Med Chem       Date:  1975-08       Impact factor: 7.446
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