Ahmet Hüseyin Acar1, Ümit Yolcu2, Mehmet Gül3, Ali Keleş4, Necip Fazıl Erdem5, Sevil Altundag Kahraman6. 1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, İstanbul, Turkey. Electronic address: ahmethuseyinacar@gmail.com. 2. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Inonu University, Malatya,Turkey. 3. Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey. 4. Department of Endodontics, Faculty of Dentistry, Inonu University, Malatya, Turkey. 5. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, İstanbul, Turkey. 6. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Abstract
OBJECTIVE: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (βTCP). DESIGN: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PRF, Straumann(®) Bone Ceramic (SBC), or PRF+SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4 (T1) and 10 at week 8 (T2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. RESULTS: Histomorphometric and micro-CT analysis showed that both PRF and SBC significantly increased bone regeneration at T1 and T2 (P<0.01). When PRF was used in combination with HA/βTCP, a further significant increase in new bone formation was observed at T1 and T2 compared with that when PRF or SBC was used alone (P<0.01). CONCLUSIONS: PRF has a positive effect on bone formation when used alone and in combination with HA/βTCP.
OBJECTIVE: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (βTCP). DESIGN: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PRF, Straumann(®) Bone Ceramic (SBC), or PRF+SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4 (T1) and 10 at week 8 (T2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. RESULTS: Histomorphometric and micro-CT analysis showed that both PRF and SBC significantly increased bone regeneration at T1 and T2 (P<0.01). When PRF was used in combination with HA/βTCP, a further significant increase in new bone formation was observed at T1 and T2 compared with that when PRF or SBC was used alone (P<0.01). CONCLUSIONS: PRF has a positive effect on bone formation when used alone and in combination with HA/βTCP.
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Authors: Matheus Afm Santos; Daniela N Silva; Karla Rovaris; Frederico B Sousa; Eugenia LA Dantas; Lucas A Loureiro; Thiago M C Pereira; Silvana S Meyrelles; Rossiene M Bertollo; Elisardo C Vasquez Journal: Front Physiol Date: 2022-02-25 Impact factor: 4.566
Authors: Hakki Oguz Kazancioglu; Sertac Aksakalli; Seref Ezirganli; Muhammet Birlik; Mukaddes Esrefoglu; Ahmet Hüseyin Acar Journal: Drug Des Devel Ther Date: 2015-12-21 Impact factor: 4.162
Authors: Şeref Ezirganli; Hakki Oğuz Kazancioğlu; Ahmet Hüseyin Acar; Hakan Özdemir; Emre Kuzu; Deniz Şahin İnan Journal: Exp Ther Med Date: 2017-03-01 Impact factor: 2.447