| Literature DB >> 25621110 |
Gustavo Torres de Souza1, Claudinéia Pereira Maranduba1, Camila Maurmann de Souza1, Danielle Luciana Aurora Soares do Amaral1, Francisco Carlos da Guia1, Rafaella de Souza Salomão Zanette1, João Vitor Paes Rettore1, Natana Chaves Rabelo1, Lucas Mendes Nascimento1, Ícaro França Navarro Pinto1, Júlia Boechat Farani1, Abrahão Elias Hallack Neto1, Fernando de Sá Silva1, Carlos Magno da Costa Maranduba1, Angelo Atalla1.
Abstract
Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-the-art concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.Entities:
Keywords: Embryonic stem cells; Hematopoietic stem cells; Induced pluripotent stem cells; Progenitor; Reprogramming
Year: 2015 PMID： 25621110 PMCID： PMC4300920 DOI： 10.4252/wjsc.v7.i1.106
Source DB: PubMed Journal: World J Stem Cells ISSN： 1948-0210 Impact factor: 5.326