| Literature DB >> 25620792 |
Ethel R Pereira1, Dennis Jones1, Keehoon Jung1, Timothy P Padera2.
Abstract
Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.Entities:
Keywords: Chemokine; Clonality; Lymph node; Lymphangiogenesis; Lymphatic vessels; Metastasis
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Year: 2015 PMID: 25620792 PMCID: PMC4397158 DOI: 10.1016/j.semcdb.2015.01.008
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN: 1084-9521 Impact factor: 7.727