Literature DB >> 25620792

The lymph node microenvironment and its role in the progression of metastatic cancer.

Ethel R Pereira1, Dennis Jones1, Keehoon Jung1, Timothy P Padera2.   

Abstract

Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Chemokine; Clonality; Lymph node; Lymphangiogenesis; Lymphatic vessels; Metastasis

Mesh:

Substances:

Year:  2015        PMID: 25620792      PMCID: PMC4397158          DOI: 10.1016/j.semcdb.2015.01.008

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN: 1084-9521            Impact factor:   7.727


  107 in total

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Authors:  H E Wiley; E B Gonzalez; W Maki; M T Wu; S T Hwang
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Review 2.  Significance and mechanism of lymph node metastasis in cancer progression.

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Journal:  Cancer Res       Date:  2011-01-06       Impact factor: 12.701

3.  Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression.

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4.  B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma.

Authors:  Alanna Ruddell; Maria I Harrell; Momoko Furuya; Sara B Kirschbaum; Brian M Iritani
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5.  Lymphatic metastasis in the absence of functional intratumor lymphatics.

Authors:  Timothy P Padera; Ananth Kadambi; Emmanuelle di Tomaso; Carla Mouta Carreira; Edward B Brown; Yves Boucher; Noah C Choi; Douglas Mathisen; John Wain; Eugene J Mark; Lance L Munn; Rakesh K Jain
Journal:  Science       Date:  2002-04-25       Impact factor: 47.728

6.  Simultaneous targeting of CD3 on T cells and CD40 on B or dendritic cells augments the antitumor reactivity of tumor-primed lymph node cells.

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Journal:  J Immunol       Date:  2005-08-01       Impact factor: 5.422

7.  Extralymphatic tumors prepare draining lymph nodes to invasion via a T-cell cross-tolerance process.

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Review 8.  Emerging lymphatic imaging technologies for mouse and man.

Authors:  Eva M Sevick-Muraca; Sunkuk Kwon; John C Rasmussen
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9.  Tumor induction of VEGF promoter activity in stromal cells.

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Authors:  Benjamin J Vakoc; Ryan M Lanning; James A Tyrrell; Timothy P Padera; Lisa A Bartlett; Triantafyllos Stylianopoulos; Lance L Munn; Guillermo J Tearney; Dai Fukumura; Rakesh K Jain; Brett E Bouma
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  61 in total

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2.  CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers.

Authors:  Subhashree Kumaravel; Sumeet Singh; Sukanya Roy; Lavanya Venkatasamy; Tori K White; Samiran Sinha; Shannon S Glaser; Stephen H Safe; Sanjukta Chakraborty
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Review 3.  Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal.

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Review 4.  The Lymphatic System in Disease Processes and Cancer Progression.

Authors:  Timothy P Padera; Eelco F J Meijer; Lance L Munn
Journal:  Annu Rev Biomed Eng       Date:  2016-02-05       Impact factor: 9.590

5.  Lymph node effective vascular permeability and chemotherapy uptake.

Authors:  Eelco F J Meijer; Cedric Blatter; Ivy X Chen; Echoe Bouta; Dennis Jones; Ethel R Pereira; Keehoon Jung; Benjamin J Vakoc; James W Baish; Timothy P Padera
Journal:  Microcirculation       Date:  2017-08       Impact factor: 2.628

6.  Biomimetic on-a-chip platforms for studying cancer metastasis.

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7.  A role for BRG1 in the regulation of genes required for development of the lymphatic system.

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8.  CD169 identifies an activated CD8(+) T cell subset in regional lymph nodes that predicts favorable prognosis in colorectal cancer patients.

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Review 9.  The dynamic control of signal transduction networks in cancer cells.

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10.  Determination of a CD4+CD25-FoxP3+ T cells subset in tumor-draining lymph nodes of colorectal cancer secreting IL-2 and IFN-γ.

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