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Literature DB >> 25618641

Electrochemical determination of the anticancer drug taxol at a ds-DNA modified pencil-graphite electrode and its application as a label-free electrochemical biosensor.

Somayeh Tajik¹, Mohammad Ali Taher², Hadi Beitollahi³, Mosoud Torkzadeh-Mahani⁴.

Abstract

In this study a novel biosensor for determination of taxol is described. The interaction of taxol with salmon-sperm double-stranded DNA (ds-DNA) based on the decreasing of the oxidation signals of guanine and adenine bases was studied electrochemically with a pencil-graphite electrode (PGE) using a differential pulse voltammetry (DPV) method. The decreases in the intensity of the guanine and adenine oxidation signals after interaction with taxol were used as indicator signals for the sensitive determination of taxol. DPV exhibits a linear dynamic range of 2.0×10(-7)-1.0×10(-5) M for taxol with a detection limit of 8.0×10(-8) M. Finally, this modified electrode was used for determination of taxol in some real samples.

Entities: Chemical

Keywords: Anticancer drug determination; DNA biosensor; Double-stranded DNA; Pencil-graphite electrode; Taxol

Mesh：

Substances：

Year: 2014 PMID： 25618641 DOI： 10.1016/j.talanta.2014.10.063

Source DB: PubMed Journal: Talanta ISSN： 0039-9140 Impact factor: 6.057

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Cited

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Electrochemical determination of the anticancer drug taxol at a ds-DNA modified pencil-graphite electrode and its application as a label-free electrochemical biosensor.

1. Theoretical investigation into the cooperativity effect between the intermolecular π∙π and H-bonding interactions in the curcumin∙cytosine∙H₂O system.

Review 2. Developments and applications of nanomaterial-based carbon paste electrodes.

3. Direct electrochemical detection of clozapine by RuO₂ nanoparticles-modified screen-printed electrode.

4. Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe₃O₄/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine.

Review 5. What Can Electrochemical Methods Offer in Determining DNA-Drug Interactions?

Review 6. Recent Advances in Electrochemical Sensors and Biosensors for Detecting Bisphenol A.

Review 7. Optical Biosensors for Therapeutic Drug Monitoring.

Electrochemical determination of the anticancer drug taxol at a ds-DNA modified pencil-graphite electrode and its application as a label-free electrochemical biosensor.

1. Theoretical investigation into the cooperativity effect between the intermolecular π∙π and H-bonding interactions in the curcumin∙cytosine∙H2O system.

Review 2. Developments and applications of nanomaterial-based carbon paste electrodes.

3. Direct electrochemical detection of clozapine by RuO2 nanoparticles-modified screen-printed electrode.

4. Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe3O4/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine.

Review 5. What Can Electrochemical Methods Offer in Determining DNA-Drug Interactions?

Review 6. Recent Advances in Electrochemical Sensors and Biosensors for Detecting Bisphenol A.

Review 7. Optical Biosensors for Therapeutic Drug Monitoring.

1. Theoretical investigation into the cooperativity effect between the intermolecular π∙π and H-bonding interactions in the curcumin∙cytosine∙H₂O system.

3. Direct electrochemical detection of clozapine by RuO₂ nanoparticles-modified screen-printed electrode.

4. Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe₃O₄/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine.