Frederic Castinetti1, Mouna Sahnoun2, Frederique Albarel2, Isabelle Morange2, Melanie Philippon2, Bernard Conte-Devolx2, Thierry Brue2. 1. Service d'endocrinologie, centre de référence DEFHY, hôpital de la Timone, Aix-Marseille université, rue Saint-Pierre, 13005 Marseille, France. Electronic address: Frederic.castinetti@ap-hm.fr. 2. Service d'endocrinologie, centre de référence DEFHY, hôpital de la Timone, Aix-Marseille université, rue Saint-Pierre, 13005 Marseille, France.
Abstract
BACKGROUND: Patients suffering from adrenal insufficiency, whether primary (PAI) or secondary (SAI) have an increased mortality risk and increased morbidity. There are no guidelines on hydrocortisone replacement therapy and little is known on patients' management in current practice. We described patients' profiles and treatment in a tertiary referral centre. METHODS: Data were collected retrospectively from medical charts. PAI and SAI patients were described and compared. RESULTS: Two hundred and one patients (79 PAI+122 SAI) were included. They had a mean duration of disease of 11.2years. Main causes of PAI were autoimmune diseases (31%) and adrenalectomy (26%). SAI was caused primarily by pituitary tumors (61%) and irradiation (20%). Mean dose of daily hydrocortisone (HC) was 27.5 and 19.9mg/day in PAI and SAI patients respectively, with a majority of patients dividing the dose into 2 intakes (46.8 and 72.2% in PAI and SAI groups, respectively). SAI patients exhibited more cardiovascular risk factors than PAI patients. The HC daily dose was slightly higher in patients with dyslipidemia (in both PAI and SAI groups) and in those with high blood pressure (in the SAI group only). One third of patients were out of work, due to unemployment, sick leaves, or disability. CONCLUSIONS: The management of AI is far from standardized, and individual tailorization is difficult with currently available means of treatment. Under- and overdose of hydrocortisone likely leads to complications, and altered quality of life reflected by a high rate of "out of work" patients.
BACKGROUND:Patients suffering from adrenal insufficiency, whether primary (PAI) or secondary (SAI) have an increased mortality risk and increased morbidity. There are no guidelines on hydrocortisone replacement therapy and little is known on patients' management in current practice. We described patients' profiles and treatment in a tertiary referral centre. METHODS: Data were collected retrospectively from medical charts. PAI and SAI patients were described and compared. RESULTS: Two hundred and one patients (79 PAI+122 SAI) were included. They had a mean duration of disease of 11.2years. Main causes of PAI were autoimmune diseases (31%) and adrenalectomy (26%). SAI was caused primarily by pituitary tumors (61%) and irradiation (20%). Mean dose of daily hydrocortisone (HC) was 27.5 and 19.9mg/day in PAI and SAI patients respectively, with a majority of patients dividing the dose into 2 intakes (46.8 and 72.2% in PAI and SAI groups, respectively). SAI patients exhibited more cardiovascular risk factors than PAIpatients. The HC daily dose was slightly higher in patients with dyslipidemia (in both PAI and SAI groups) and in those with high blood pressure (in the SAI group only). One third of patients were out of work, due to unemployment, sick leaves, or disability. CONCLUSIONS: The management of AI is far from standardized, and individual tailorization is difficult with currently available means of treatment. Under- and overdose of hydrocortisone likely leads to complications, and altered quality of life reflected by a high rate of "out of work" patients.
Authors: Chiara Graziadio; Valeria Hasenmajer; Mary A Venneri; Daniele Gianfrilli; Andrea M Isidori; Emilia Sbardella Journal: Front Endocrinol (Lausanne) Date: 2018-08-03 Impact factor: 5.555