Literature DB >> 25617175

Gonadotrophin replacement for induction of fertility in hypogonadal men.

Andrew A Dwyer1, Taneli Raivio2, Nelly Pitteloud3.   

Abstract

Congenital hypogonadotrophic hypogonadism (CHH) is a rare form of infertility caused by deficient secretion or action of gonadotrophin-releasing hormone. There is no consensus regarding the optimal approach to fertility treatment in CHH men. In most cases, appropriate hormonal treatment with human chorionic gonadotrophin with or without follicle stimulating hormone will induce testicular development, spermatogenesis and fertility. Recent studies have examined sequential treatment with FSH pre-treatment to optimize fertility outcomes in severely affected CHH patients. This paper reviews historical and recent literature to summarize the current evidence on therapeutic approaches for CHH men seeking fertility.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GnRH deficiency; Kallmann syndrome; fertility outcomes; fertility treatment; gonadotrophin therapy; hypogonadotrophic hypogonadism; male fertility

Mesh：

Substances：

Year:  2014        PMID： 25617175     DOI： 10.1016/j.beem.2014.10.005

Source DB:  PubMed          Journal:  Best Pract Res Clin Endocrinol Metab        ISSN： 1521-690X            Impact factor:   4.690


  24 in total

Review 1.  Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.

Authors:  Ulrich Boehm; Pierre-Marc Bouloux; Mehul T Dattani; Nicolas de Roux; Catherine Dodé; Leo Dunkel; Andrew A Dwyer; Paolo Giacobini; Jean-Pierre Hardelin; Anders Juul; Mohamad Maghnie; Nelly Pitteloud; Vincent Prevot; Taneli Raivio; Manuel Tena-Sempere; Richard Quinton; Jacques Young
Journal:  Nat Rev Endocrinol       Date:  2015-07-21       Impact factor: 43.330

2.  Treatment of congenital hypogonadotropic hypogonadism in male patients.

Authors:  Hae Sang Lee; Young Suk Shim; Jin Soon Hwang
Journal:  Ann Pediatr Endocrinol Metab       Date:  2022-09-30

Review 3.  Late endocrine effects of childhood cancer.

Authors:  Susan R Rose; Vincent E Horne; Jonathan Howell; Sarah A Lawson; Meilan M Rutter; Gylynthia E Trotman; Sarah D Corathers
Journal:  Nat Rev Endocrinol       Date:  2016-04-01       Impact factor: 43.330

Review 4.  Arachnoid cyst: a further anomaly associated with Kallmann syndrome?

Authors:  Luca Massimi; Alessandro Izzo; Giovanna Paternoster; Paolo Frassanito; Concezio Di Rocco
Journal:  Childs Nerv Syst       Date:  2016-07-05       Impact factor: 1.475

5.  Efficacy of follitropin-alpha versus human menopausal gonadotropin for male patients with congenital hypogonadotropic hypogonadism.

Authors:  Mazhar Ortaç; Muhammed Hıdır; Nusret Can Çilesiz; Ateş Kadıoğlu
Journal:  Turk J Urol       Date:  2019-11-29

Review 6.  Male infertility due to testicular disorders.

Authors:  Aditi Sharma; Suks Minhas; Waljit S Dhillo; Channa N Jayasena
Journal:  J Clin Endocrinol Metab       Date:  2021-01-23       Impact factor: 5.958

7.  Reproductive outcomes of microdissection testicular sperm extraction in hypogonadotropic hypogonadal azoospermic men after gonadotropin therapy.

Authors:  Yu-Kuang Chen; I-Shen Huang; Wei-Jen Chen; Chen-Yu Huang; Chi-Hong Ho; Eric Yi-Hsiu Huang; William J Huang
Journal:  J Assist Reprod Genet       Date:  2021-05-12       Impact factor: 3.357

8.  Prior testosterone replacement therapy may impact spermatogenic response to combined gonadotropin therapy in severe congenital hypogonadotropic hypogonadism.

Authors:  Ravikumar Shah; Virendra Patil; Vijaya Sarathi; Anurag R Lila; Margaret Zacharin; Brijesh Krishnappa; Manjeetkaur Sehemby; Sanjeet Kumar Jaiswal; Pratap L Jadhav; Swati Ramteke-Jadhav; Nalini Shah; Tushar Bandgar
Journal:  Pituitary       Date:  2020-11-23       Impact factor: 4.107

9.  Changes in Bone Mineral Density and Metabolic Parameters after Pulsatile Gonadorelin Treatment in Young Men with Hypogonadotropic Hypogonadism.

Authors:  Chen-Xi Li; Song-Tao Tang; Qiu Zhang
Journal:  Int J Endocrinol       Date:  2015-08-31       Impact factor: 3.257

10.  Evaluating the Combination of Human Chorionic Gonadotropin and Clomiphene Citrate in Treatment of Male Hypogonadotropic Hypogonadism: A Prospective Study.

Authors:  The Son Trinh; Nguyen Ba Hung; Le Thi Thu Hien; Ngo Anh Tuan; Dinh Cong Pho; Quan Anh Dung; Duc Anh Do; Ha Duc Quang; Hoang Van Ai; Pham Ngoc Hung
Journal:  Res Rep Urol       Date:  2021-06-15
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