BACKGROUND: The ability for patients to understand their risk for disease is important to early intervention and effective treatment. The link between individual cardiovascular risk factors and cognition has been well-established. PURPOSE: This study investigated the relationship between cognition and a combination of these factors through a single composite risk score. METHODS: This study quantitatively summarized the strength of the association between composite cardiovascular risk scores and cognitive test performance using meta-analytic methods. RESULTS: One hundred and nine effect sizes were obtained from 19 studies employing 54,564 participants. Composite risk scores showed a significant association (r=-0.16) with cognitive test performance. Cognitive domain and age did not significantly modify this relationship. CONCLUSIONS: Composite cardiovascular risk scores can be useful indicators of future cognition. The development of a dementia risk score using similar risk factors could aid in the assessment and lifestyle interventions of persons at risk for dementia.
BACKGROUND: The ability for patients to understand their risk for disease is important to early intervention and effective treatment. The link between individual cardiovascular risk factors and cognition has been well-established. PURPOSE: This study investigated the relationship between cognition and a combination of these factors through a single composite risk score. METHODS: This study quantitatively summarized the strength of the association between composite cardiovascular risk scores and cognitive test performance using meta-analytic methods. RESULTS: One hundred and nine effect sizes were obtained from 19 studies employing 54,564 participants. Composite risk scores showed a significant association (r=-0.16) with cognitive test performance. Cognitive domain and age did not significantly modify this relationship. CONCLUSIONS: Composite cardiovascular risk scores can be useful indicators of future cognition. The development of a dementia risk score using similar risk factors could aid in the assessment and lifestyle interventions of persons at risk for dementia.
Authors: Spencer W Liebel; Erin C Jones; Assaf Oshri; Emily S Hallowell; Beth A Jerskey; John Gunstad; Lawrence H Sweet Journal: Neuropsychology Date: 2016-11-14 Impact factor: 3.295
Authors: Christian LoBue; David Denney; Linda S Hynan; Heidi C Rossetti; Laura H Lacritz; John Hart; Kyle B Womack; Fu L Woon; C Munro Cullum Journal: J Alzheimers Dis Date: 2016 Impact factor: 4.472
Authors: Elizabeth A Boots; Karla J Castellanos; Liang Zhan; Lisa L Barnes; Lisa Tussing-Humphreys; Sean C L Deoni; Melissa Lamar Journal: Front Aging Neurosci Date: 2020-10-30 Impact factor: 5.750