Literature DB >> 25615875

Development of gemcitabine-adsorbed magnetic gelatin nanoparticles for targeted drug delivery in lung cancer.

Senay Hamarat Sanlıer1, Merve Yasa1, Aslı Ozge Cihnioglu1, Merve Abdulhayoglu1, Habibe Yılmaz1, Güliz Ak1.   

Abstract

Magnetic iron oxide nanoparticles (IONPs) were coated with gelatin type B by means of the two-step desolvation method. Drug loading by adsorption was studied under various conditions such as different temperature, contact time, pH, and initial gemcitabine concentration. Further, Langmuir isotherm curves were constracted and constants were calculated. According to the Langmuir isotherm, the Gibbs free energy of the adsorption process at 25°C was - 4.74 kJ/mol. On the other hand, this value at 37°C was - 7.86 kJ/mol. In vitro drug release was performed at pH levels of 5 and 7.4, with gemcitabine-loaded magnetic gelatin nanoparticles and free gemcitabine, and both the results were subsequently compared.

Entities:  

Keywords:  adsorption; drug delivery; gemcitabine; isotherm; kinetic modeling; magnetic gelatin nanoparticles

Mesh：

Substances：

Year:  2015        PMID： 25615875     DOI： 10.3109/21691401.2014.1001493

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  6 in total

Review 1.  Diverse Applications of Nanomedicine.

Authors:  Beatriz Pelaz; Christoph Alexiou; Ramon A Alvarez-Puebla; Frauke Alves; Anne M Andrews; Sumaira Ashraf; Lajos P Balogh; Laura Ballerini; Alessandra Bestetti; Cornelia Brendel; Susanna Bosi; Monica Carril; Warren C W Chan; Chunying Chen; Xiaodong Chen; Xiaoyuan Chen; Zhen Cheng; Daxiang Cui; Jianzhong Du; Christian Dullin; Alberto Escudero; Neus Feliu; Mingyuan Gao; Michael George; Yury Gogotsi; Arnold Grünweller; Zhongwei Gu; Naomi J Halas; Norbert Hampp; Roland K Hartmann; Mark C Hersam; Patrick Hunziker; Ji Jian; Xingyu Jiang; Philipp Jungebluth; Pranav Kadhiresan; Kazunori Kataoka; Ali Khademhosseini; Jindřich Kopeček; Nicholas A Kotov; Harald F Krug; Dong Soo Lee; Claus-Michael Lehr; Kam W Leong; Xing-Jie Liang; Mei Ling Lim; Luis M Liz-Marzán; Xiaowei Ma; Paolo Macchiarini; Huan Meng; Helmuth Möhwald; Paul Mulvaney; Andre E Nel; Shuming Nie; Peter Nordlander; Teruo Okano; Jose Oliveira; Tai Hyun Park; Reginald M Penner; Maurizio Prato; Victor Puntes; Vincent M Rotello; Amila Samarakoon; Raymond E Schaak; Youqing Shen; Sebastian Sjöqvist; Andre G Skirtach; Mahmoud G Soliman; Molly M Stevens; Hsing-Wen Sung; Ben Zhong Tang; Rainer Tietze; Buddhisha N Udugama; J Scott VanEpps; Tanja Weil; Paul S Weiss; Itamar Willner; Yuzhou Wu; Lily Yang; Zhao Yue; Qian Zhang; Qiang Zhang; Xian-En Zhang; Yuliang Zhao; Xin Zhou; Wolfgang J Parak
Journal:  ACS Nano       Date:  2017-03-14       Impact factor: 15.881

2.  Gelatin Nanoparticles for Targeted Dual Drug Release out of Alginate-di-Aldehyde-Gelatin Gels.

Authors:  Sophie Schrade; Lucas Ritschl; Regine Süss; Pia Schilling; Michael Seidenstuecker
Journal:  Gels       Date:  2022-06-08

3.  The role of iron in pulmonary pathology.

Authors:  Heena Khiroya; Alice M Turner
Journal:  Multidiscip Respir Med       Date:  2015-12-01

4.  Preparation of Ligand Brush Nanocapsules for Robust Self-Controlled Antimicrobial Activity with Low Cytotoxicity at Target pH and Humidity.

Authors:  Eunjoo Koh; Yong Taek Lee
Journal:  Pharmaceutics       Date:  2022-01-25       Impact factor: 6.321

Review 5.  Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity.

Authors:  Laís Salomão Arias; Juliano Pelim Pessan; Ana Paula Miranda Vieira; Taynara Maria Toito de Lima; Alberto Carlos Botazzo Delbem; Douglas Roberto Monteiro
Journal:  Antibiotics (Basel)       Date:  2018-06-09

Review 6.  Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment.

Authors:  Ka Hong Wong; Aiping Lu; Xiaoyu Chen; Zhijun Yang
Journal:  Molecules       Date:  2020-08-09       Impact factor: 4.411
  6 in total

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