| Literature DB >> 25614590 |
Anthony Morel1, Christophe Passot2, Christophe Arnoult2, Amélie Dumans1, Elodie Beaumont1, Valérie Gouilleux-Gruart2, Philippe Roingeard1, Emmanuelle Blanchard1.
Abstract
The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.Entities:
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Year: 2015 PMID： 25614590 DOI： 10.1099/vir.0.000060
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891