Francesco Giganti1, Elena Orsenigo2, Paolo Giorgio Arcidiacono3, Roberto Nicoletti4, Luca Albarello5, Alessandro Ambrosi6, Annalaura Salerno4, Antonio Esposito4, Maria Chiara Petrone3, Damiano Chiari2, Carlo Staudacher2, Alessandro Del Maschio4, Francesco De Cobelli4. 1. Department of Radiology and Centre for Experimental Imaging, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy. giganti.fra@gmail.com. 2. Department of Surgery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 3. Department of Gastroenterology and Gastrointestinal Endoscopy, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 4. Department of Radiology and Centre for Experimental Imaging, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy. 5. Pathology Unit, San Raffaele Scientific Institute, Milan, Italy. 6. Vita-Salute San Raffaele University, Milan, Italy.
Abstract
BACKGROUND: The aim of this study was to prospectively compare the diagnostic performance of magnetic resonance imaging (MRI), multidetector computed tomography (MDCT) and endoscopic ultrasonography (EUS) in the preoperative locoregional staging of gastric cancer. METHODS: This study had Institutional Review Board approval, and informed consent was obtained from all patients. Fifty-two patients with biopsy-proven gastric cancer underwent preoperative 1.5-T MRI, 64-channel MDCT and EUS. All images were analysed blind, and the results were compared with histopathological findings according to the seventh edition of the TNM classification. After the population had been divided on the basis of the local invasion (T1-3 vs T4a-b) and nodal involvement (N0 vs N+), sensitivity, specificity, positive and negative predictive value, and accuracy were calculated and diagnostic performance measures were assessed using the McNemar test. RESULTS: For T staging, EUS showed higher sensitivity (94%) than MDCT and MRI (65 and 76%; p = 0.02 and p = 0.08). MDCT and MRI had significantly higher specificity (91 and 89%) than EUS (60%) (p = 0.0009 and p = 0.003). Adding MRI to MDCT or EUS did not result in significant differences for sensitivity. For N staging, EUS showed higher sensitivity (92%) than MRI and MDCT (69 and 73%; p = 0.01 and p = 0.02). MDCT showed better specificity (81%) than EUS and MRI (58 and 73%; p = 0.03 and p = 0.15). CONCLUSIONS: Our prospective study confirmed the leading role of EUS and MDCT in the staging of gastric cancer and did not prove, at present, the value of the clinical use of MRI.
BACKGROUND: The aim of this study was to prospectively compare the diagnostic performance of magnetic resonance imaging (MRI), multidetector computed tomography (MDCT) and endoscopic ultrasonography (EUS) in the preoperative locoregional staging of gastric cancer. METHODS: This study had Institutional Review Board approval, and informed consent was obtained from all patients. Fifty-two patients with biopsy-proven gastric cancer underwent preoperative 1.5-T MRI, 64-channel MDCT and EUS. All images were analysed blind, and the results were compared with histopathological findings according to the seventh edition of the TNM classification. After the population had been divided on the basis of the local invasion (T1-3 vs T4a-b) and nodal involvement (N0 vs N+), sensitivity, specificity, positive and negative predictive value, and accuracy were calculated and diagnostic performance measures were assessed using the McNemar test. RESULTS: For T staging, EUS showed higher sensitivity (94%) than MDCT and MRI (65 and 76%; p = 0.02 and p = 0.08). MDCT and MRI had significantly higher specificity (91 and 89%) than EUS (60%) (p = 0.0009 and p = 0.003). Adding MRI to MDCT or EUS did not result in significant differences for sensitivity. For N staging, EUS showed higher sensitivity (92%) than MRI and MDCT (69 and 73%; p = 0.01 and p = 0.02). MDCT showed better specificity (81%) than EUS and MRI (58 and 73%; p = 0.03 and p = 0.15). CONCLUSIONS: Our prospective study confirmed the leading role of EUS and MDCT in the staging of gastric cancer and did not prove, at present, the value of the clinical use of MRI.
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Authors: Francesco De Cobelli; Francesco Giganti; Elena Orsenigo; Michaela Cellina; Antonio Esposito; Giulia Agostini; Luca Albarello; Elena Mazza; Alessandro Ambrosi; Carlo Socci; Carlo Staudacher; Alessandro Del Maschio Journal: Eur Radiol Date: 2013-04-16 Impact factor: 5.315
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Authors: Francesco Giganti; Sofia Antunes; Annalaura Salerno; Alessandro Ambrosi; Paolo Marra; Roberto Nicoletti; Elena Orsenigo; Damiano Chiari; Luca Albarello; Carlo Staudacher; Antonio Esposito; Alessandro Del Maschio; Francesco De Cobelli Journal: Eur Radiol Date: 2016-08-23 Impact factor: 5.315
Authors: Victor Mihai Sacerdotianu; Bogdan Silviu Ungureanu; Sevastita Iordache; Maria Monalisa Filip; Daniel Pirici; Ilona Mihaela Liliac; Adrian Saftoiu Journal: Curr Health Sci J Date: 2022-03-31
Authors: Francesco Giganti; Alessandro Ambrosi; Damiano Chiari; Elena Orsenigo; Antonio Esposito; Elena Mazza; Luca Albarello; Carlo Staudacher; Alessandro Del Maschio; Francesco De Cobelli Journal: Chin J Cancer Res Date: 2017-04 Impact factor: 5.087