Literature DB >> 25614037

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions.

Fabio Doro1, Cinzia Colombo, Chiara Alberti, Daniela Arosio, Laura Belvisi, Cesare Casagrande, Roberto Fanelli, Leonardo Manzoni, Emilio Parisini, Umberto Piarulli, Elena Luison, Mariangela Figini, Antonella Tomassetti, Monica Civera.   

Abstract

We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients.

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Year:  2015        PMID： 25614037     DOI： 10.1039/c4ob02538e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Exploring E-cadherin-peptidomimetics interaction using NMR and computational studies.

Authors:  Monica Civera; Francesca Vasile; Donatella Potenza; Cinzia Colombo; Sara Parente; Chiara Vettraino; Tommaso Prosdocimi; Emilio Parisini; Laura Belvisi
Journal:  PLoS Comput Biol       Date:  2019-06-03       Impact factor: 4.475

2.  Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion.

Authors:  Akinobu Senoo; Sho Ito; Satoru Nagatoishi; Yutaro Saito; Go Ueno; Daisuke Kuroda; Kouhei Yoshida; Takumi Tashima; Shota Kudo; Shinsuke Sando; Kouhei Tsumoto
Journal:  Commun Biol       Date:  2021-09-07

3.  A combined fragment-based virtual screening and STD-NMR approach for the identification of E-cadherin ligands.

Authors:  Francesca Vasile; Francesca Lavore; Silvia Gazzola; Chiara Vettraino; Emilio Parisini; Umberto Piarulli; Laura Belvisi; Monica Civera
Journal:  Front Chem       Date:  2022-08-19       Impact factor: 5.545

Review 4.  Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells.

Authors:  Francesca Roggiani; Delia Mezzanzanica; Katia Rea; Antonella Tomassetti
Journal:  Int J Mol Sci       Date:  2016-08-23       Impact factor: 5.923

5.  Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth.

Authors:  Katia Rea; Francesca Roggiani; Loris De Cecco; Francesco Raspagliesi; Maria Luisa Carcangiu; Joyce Nair-Menon; Marina Bagnoli; Ileana Bortolomai; Delia Mezzanzanica; Silvana Canevari; Antonis Kourtidis; Panos Z Anastasiadis; Antonella Tomassetti
Journal:  J Exp Clin Cancer Res       Date:  2018-07-11

Review 6.  N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer.

Authors:  Krzysztof Marek Mrozik; Orest William Blaschuk; Chee Man Cheong; Andrew Christopher William Zannettino; Kate Vandyke
Journal:  BMC Cancer       Date:  2018-10-01       Impact factor: 4.430
  6 in total

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