Literature DB >> 2561393

Rat brain capillary endothelial cells express functional PDGF B-type receptors.

A Smits1, M Hermansson, M Nistér, I Karnushina, C H Heldin, B Westermark, K Funa.   

Abstract

Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) B-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [125I]PDGF-BB but not [125I]PDGF-AA, suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [3H]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2561393     DOI： 10.3109/08977198909069076

Source DB:  PubMed          Journal:  Growth Factors        ISSN： 0897-7194            Impact factor:   2.511


  21 in total

1.  Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.

Authors:  A Smits; K Funa; F S Vassbotn; M Beausang-Linder; F af Ekenstam; C H Heldin; B Westermark; M Nistér
Journal:  Am J Pathol       Date:  1992-03       Impact factor: 4.307

2.  Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study.

Authors:  S Tanizawa; M Ueda; C M van der Loos; A C van der Wal; A E Becker
Journal:  Heart       Date:  1996-06       Impact factor: 5.994

3.  Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase.

Authors:  L Lehtola; M Nistér; E Hölttä; B Westermark; K Alitalo
Journal:  Cell Regul       Date:  1991-08

4.  Platelet-derived growth factor indirectly stimulates angiogenesis in vitro.

Authors:  N Sato; J G Beitz; J Kato; M Yamamoto; J W Clark; P Calabresi; A Raymond; A R Frackelton
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

5.  Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

Authors:  M Marx; R A Perlmutter; J A Madri
Journal:  J Clin Invest       Date:  1994-01       Impact factor: 14.808

6.  Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans.

Authors:  C Reuterdahl; C Sundberg; K Rubin; K Funa; B Gerdin
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

7.  Human microvascular endothelial cells express receptors for platelet-derived growth factor.

Authors:  J G Beitz; I S Kim; P Calabresi; A R Frackelton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

8.  Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma.

Authors:  C Sundberg; M Ljungström; G Lindmark; B Gerdin; K Rubin
Journal:  Am J Pathol       Date:  1993-11       Impact factor: 4.307

9.  Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.

Authors:  A Smits; M Kato; B Westermark; M Nistér; C H Heldin; K Funa
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

Review 10.  Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects.

Authors:  E J Battegay
Journal:  J Mol Med (Berl)       Date:  1995-07       Impact factor: 4.599
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.