UNLABELLED: The purpose of this study was to evaluate the impact of changes to a patient's prandial status, metabolic status (rest vs. exercise), and peripheral blood flow (via caffeine or warming) on the uptake of (99m)Tc-sestamibi in breast tissue. METHODS: A total of 154 subjects participated in 1 of 4 study groups that evaluated the effects of 4 types of intervention on the uptake of (99m)Tc-sestamibi in breast tissue (effect of fasting, light exercise, caffeine, and peripheral warming). Molecular breast imaging was performed before and after each intervention. Count density was assessed in counts/cm(2)/MBq from the mediolateral oblique view in all studies. RESULTS: Uptake of (99m)Tc-sestamibi in breast tissue increased by approximately 25% from 6.6 counts/cm(2)/MBq in the fed state to 8.3 counts/cm(2)/MBq with fasting. Peripheral warming also resulted in an approximately 20% increase in count density from 9.1 to 10.9 counts/cm(2)/MBq. Conversely, exercise caused a 35% drop in count density relative to the resting state. Uptake did not seem to be influenced by caffeine and did not correlate with a patient's height, weight, or breast thickness. There was only a weak correlation between breast activity and body surface area. CONCLUSION: The combined effects of fasting and warming resulted in an approximately 50% increased uptake of (99m)Tc-sestamibi in breast tissue relative to that observed in a reference group to whom no preparatory instructions had been given. Optimal patient preparation before administration of (99m)Tc-sestamibi should permit a corresponding reduction in either acquisition time or required dose of (99m)Tc-sestamibi.
UNLABELLED: The purpose of this study was to evaluate the impact of changes to a patient's prandial status, metabolic status (rest vs. exercise), and peripheral blood flow (via caffeine or warming) on the uptake of (99m)Tc-sestamibi in breast tissue. METHODS: A total of 154 subjects participated in 1 of 4 study groups that evaluated the effects of 4 types of intervention on the uptake of (99m)Tc-sestamibi in breast tissue (effect of fasting, light exercise, caffeine, and peripheral warming). Molecular breast imaging was performed before and after each intervention. Count density was assessed in counts/cm(2)/MBq from the mediolateral oblique view in all studies. RESULTS: Uptake of (99m)Tc-sestamibi in breast tissue increased by approximately 25% from 6.6 counts/cm(2)/MBq in the fed state to 8.3 counts/cm(2)/MBq with fasting. Peripheral warming also resulted in an approximately 20% increase in count density from 9.1 to 10.9 counts/cm(2)/MBq. Conversely, exercise caused a 35% drop in count density relative to the resting state. Uptake did not seem to be influenced by caffeine and did not correlate with a patient's height, weight, or breast thickness. There was only a weak correlation between breast activity and body surface area. CONCLUSION: The combined effects of fasting and warming resulted in an approximately 50% increased uptake of (99m)Tc-sestamibi in breast tissue relative to that observed in a reference group to whom no preparatory instructions had been given. Optimal patient preparation before administration of (99m)Tc-sestamibi should permit a corresponding reduction in either acquisition time or required dose of (99m)Tc-sestamibi.
Authors: Carrie B Hruska; Amy Lynn Conners; Celine M Vachon; Michael K O'Connor; Lynne T Shuster; Adam C Bartley; Deborah J Rhodes Journal: Acad Radiol Date: 2015-06-22 Impact factor: 3.173
Authors: Michael K O'Connor; Melissa M B Morrow; Katie N Hunt; Judy C Boughey; Dietlind L Wahner-Roedler; Amy Lynn Conners; Deborah J Rhodes; Carrie B Hruska Journal: EJNMMI Res Date: 2017-01-14 Impact factor: 3.138
Authors: Carrie B Hruska; Katie N Hunt; Amy Lynn Conners; Jennifer R Geske; Kathleen R Brandt; Amy C Degnim; Celine M Vachon; Michael K O'Connor; Deborah J Rhodes Journal: Breast Cancer Res Date: 2019-03-08 Impact factor: 6.466