Albert Ariza-Solé1, Francesc Formiga2, Joel Salazar-Mendiguchía3, Alberto Garay3, Victòria Lorente3, José C Sánchez-Salado3, Guillermo Sánchez-Elvira3, Josep Gómez-Lara4, Joan A Gómez-Hospital4, Angel Cequier4. 1. Coronary Care Unit, Heart Diseases Institute, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: aariza@bellvitgehospital.cat. 2. Geriatrics Unit, Internal Medicine Department, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain. 3. Coronary Care Unit, Heart Diseases Institute, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain. 4. Interventional Cardiology Unit, Heart Diseases Institute, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
Abstract
BACKGROUND: Prognostic impact of anaemia in the elderly with acute coronary syndromes has not been specifically analysed, and little information exists about causes of mortality in this setting. METHODS: We prospectively included consecutive patients with acute coronary syndromes. Anaemia was defined as haemoglobin < 130 g/L in men, and < 120 g/L in women. Primary outcome was mid-term mortality and its causes. Analyses were performed by Cox regression method. RESULTS: We included 2128 patients, of whom 394 (18.6%) were aged 75 years or older. Anaemia was more common in the elderly (40.4% vs 19.5%, p <0.001). Mean follow-up was 386 days. Anaemia independently predicted overall mortality (HR 1.47, 95% CI 1.05-2.06), cardiac mortality (HR 1.76, 95% CI 1.06-2.94) and non-cardiac mortality (HR 1.59, 95% CI 1.03-2.45) in the overall cohort. In young patients the association between anaemia and mortality was significant only for non-cardiac causes. The association between anaemia and mortality was not significant in the elderly (HR 1.08, 95% CI 0.71-1.63, p 0.736). CONCLUSIONS: The impact of anaemia on cause specific of mortality seem to be different according to age subgroup. The association between anaemia and mortality was not observed in elderly patients from our series.
BACKGROUND: Prognostic impact of anaemia in the elderly with acute coronary syndromes has not been specifically analysed, and little information exists about causes of mortality in this setting. METHODS: We prospectively included consecutive patients with acute coronary syndromes. Anaemia was defined as haemoglobin < 130 g/L in men, and < 120 g/L in women. Primary outcome was mid-term mortality and its causes. Analyses were performed by Cox regression method. RESULTS: We included 2128 patients, of whom 394 (18.6%) were aged 75 years or older. Anaemia was more common in the elderly (40.4% vs 19.5%, p <0.001). Mean follow-up was 386 days. Anaemia independently predicted overall mortality (HR 1.47, 95% CI 1.05-2.06), cardiac mortality (HR 1.76, 95% CI 1.06-2.94) and non-cardiac mortality (HR 1.59, 95% CI 1.03-2.45) in the overall cohort. In young patients the association between anaemia and mortality was significant only for non-cardiac causes. The association between anaemia and mortality was not significant in the elderly (HR 1.08, 95% CI 0.71-1.63, p 0.736). CONCLUSIONS: The impact of anaemia on cause specific of mortality seem to be different according to age subgroup. The association between anaemia and mortality was not observed in elderly patients from our series.
Authors: Mayra Tisminetzky; Jerry H Gurwitz; Ruben Miozzo; Joel M Gore; Darleen Lessard; Jorge Yarzebski; Robert J Goldberg Journal: Am J Cardiol Date: 2019-08-08 Impact factor: 2.778
Authors: Victòria Lorente; Jaime Aboal; Cosme Garcia; Jordi Sans-Roselló; Antonia Sambola; Rut Andrea; Carlos Tomás; Gil Bonet; David Viñas; Nabil El Ouaddi; Santiago Montero; Javier Cantalapiedra; Margarida Pujol; Isabel Hernández; María Pérez-Rodriguez; Isaac Llaó; José C Sánchez-Salado; Miquel Gual; Albert Ariza-Solé Journal: J Geriatr Cardiol Date: 2020-01 Impact factor: 3.327