Literature DB >> 25612052

A new lignan with hypoglycemic activity from Tadehagi triquetrum.

Jiani Wu1, Cai yun Zhang, Tingting Zhang, Dan Zhao, Ni An, Youbin Li, Nailiang Zhu, Shuai Wang, Feng Chen, Xiaopo Zhang.   

Abstract

A new lignan named tadehaginosin, together with a known compound 3,4-dihydro-4-(4'-hydroxyphenyl)-5,7-dihydroxycoumarin, was isolated from the aerial part of Tadehagi triquetrum. The new structure was determined by various spectroscopic techniques ((1)H and (13)C APT, HSQC, HMBC, (1)H-(1)HCOSY, NOESY and HR-ESI-MS). The two isolates were evaluated for their hypoglycemic effects in vitro. Biological investigation showed that both of them possessed the capability to increase glucose consumption by HepG2 cells.

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Keywords:  Tadehagi triquetrum; hypoglycemic effects; tadehaginosin

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Year:  2015        PMID: 25612052     DOI: 10.1080/14786419.2014.1003136

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN: 1478-6419            Impact factor:   2.861


  2 in total

1.  Simultaneous measurement of tadehaginoside and its principal metabolite in rats by HPLC-MS/MS and its application in pharmacokinetics and tissue distribution study.

Authors:  Cai-Yun Zhang; Ya-Ting Lu; Yin-Feng Tan; Qi-Bing Liu; Lin Dong; Ning Ma; Wei-Ying Lu; Zhi-Heng Su; Xiao-Po Zhang
Journal:  Pharm Biol       Date:  2021-12       Impact factor: 3.503

Review 2.  The traditional ethnic herb Tadehagi triquetrum from China: a review of its phytochemistry and pharmacological activities.

Authors:  Hong-Xia Tang; Wen-Bing Sheng; Xin-Yi Liu; Pei-Wu Cui; Li-Min Gong; Qing-Ling Xie; Wen-Mao Wang; Bin Li; Wei Wang; Xu-Dong Zhou
Journal:  Pharm Biol       Date:  2022-12       Impact factor: 3.503

  2 in total

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