| Literature DB >> 25611625 |
Ya Nan Song1, Rui Hua Jiao, Wen Jing Zhang, Guo Yan Zhao, Huan Dou, Rong Jiang, Ai Hua Zhang, Ya Yi Hou, Shu Feng Bi, Hui Ming Ge, Ren Xiang Tan.
Abstract
The conversion from triene- to diene-typed ansamycins is clarified step by step in Streptomyces seoulensis IFB-A01. Such an intertype convertibility is adopted to establish for the first time the simultaneous mutasynthesis of both types of C17-benzene ansamycins (C17BAs). Three of the newly generated unnatural compounds showed potent cytotoxicity.Entities:
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Year: 2015 PMID： 25611625 DOI： 10.1021/ol5035639
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005