| Literature DB >> 25610735 |
Abstract
NF-κB is a master transcriptional regulator of inflammation that plays an important role in oncogenesis, particularly in tumors that arise in the context of inflammation. Copper metabolism MURR1 domain-containing 1 (COMMD1) is a negative regulator of NF-κB. Recent genetic-based studies in both mice and human patients indicate that COMMD1 has an important role in controlling intestinal inflammation and constraining progression to colitis-associated cancer.Entities:
Keywords: BMDM, bone marrow derived myeloid cells; CAC, colitis-associated cancer; COMMD1; COMMD1, copper metabolism MURR1 domain containing 1; GWAS, genome wide association studies; IBD, inflammatory bowel disease; IKK, IκB kinase; IκB, inhibitor of κB; K/O, knockout; LPS, lipopolysaccharide; Mye-K/O, myeloid-specific Commd1 knockout; NF-κB; NF-κB, nuclear factor-κB; SNP, single nucleotide polymorphism; WT, wild-type; colitis-associated cancer; inflammation; inflammatory bowel disease; ubiquitination
Year: 2014 PMID： 25610735 PMCID： PMC4292209 DOI： 10.4161/21624011.2014.947891
Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110